Reactions of Acid Anhydrides Flashcards
1
Q
Summary
A
- hydrolysis
- alcoholysis
- aminolysis
- with thiol
- grignard
- reduction
2
Q
Hydrolysis
A
rgts: H2O
products: 2 COOH
3
Q
Alcoholysis
A
rgts: ROH
products: RCOOR + RCOOH
4
Q
Aminolysis
A
rgts: 2 NH3
products: RCONH2 + ammonium carboxylate
rgts: 2 RNH2
products: secondary amide + RNH3+ and carboxylate
5
Q
With thiol
A
rgts: RSH and pyridine
products: thioester + pyr-H and carboxylate
6
Q
Grignard rxn
A
rgts: 2 RMgX
products: tertiary OH
7
Q
Reduction
A
rgts: LiAlH4
products: primary OH
rgts: lithium tri(t-butoxy) aluminum hydride
products: aldehyde
