Preparation of COOH Flashcards
1
Q
5 ways to prepare COOH
A
oxidation of primary OH, oxidation of alkyl benzenes, oxidative cleavage of alkynes, carboxylation of Grignard reagents, hydrolysis of nitriles
2
Q
oxidation of primary OH reagents
A
K2Cr2O7, Na2Cr2O7, CrO3 in the presence of H2O and H2SO4
3
Q
oxidation of alkyl benzenes reagents
A
KMnO4
4
Q
oxidative cleavage of alkynes rgts
A
O3 and H2O
5
Q
oxidative cleavage difference between internal alkynes and terminal alkynes
A
internal - 2 COOH products
terminal - 1 COOH and 1 CO2
6
Q
carboxylation of grignard reagents rgts
A
CO2, H3O+
7
Q
hydrolysis of nitriles rgts
A
H3O+ or NaOH, H2O
8
Q
deactivating groups
A
NO2, CN, CHO, Br, Cl
9
Q
Activating groups
A
CH3, OCH3, OH
