RBJ PHAR

Question 1

Inhibitors of post synaptic Glutamate NMDA receptors.

Used in what condition?

Answer 1

Dizocilpine, felbamate

Epilepsy

Question 2

Gabapentin MOA

Answer 2

Inhibits calcium channels on presypnaptic membrane = reduced release of glutamate NT

Question 3

Presypnaptic sodium channel blockers.

Used in epilepsy, what is their effect?

Answer 3

Reduced depolarization of the presypnaptic membrane.
Potassium bromide
Pherytoin

Question 4

Epilepsy

Answer 4

Asynchronous channel activation

Question 5

Vigabatrin

Answer 5

Inhibits GABA inactivation

Question 6

Tiagabine

Answer 6

Inhibits GABA reuptake into presynaptic membrane

Question 7

Metabolized into phenobarbitone. What is the MOA and another drug with this action?

Answer 7

Primidone
Potentiates GABAa channels
Also diazepam

Question 8

Mu opioid agonist

Answer 8

Morphine
Pethidine
Fentanyl

Question 9

Mu/ kappa agonist

Answer 9

Etorphine

Used as tranquilizer (v soluble so be careful whist handling)

Question 10

Mixed opioid drug, what action does it have on mu and kappa receptors?

Answer 10

Butophanol, buprenorphine

Mu antagonist and kappa agonist

Question 11

What actions do mu and kappa opioid channels have?

Answer 11

Mu non spinal analgesia

Kappa epidural pain and sedative

Question 12

Name two neuroleptanalgesia protocols

Answer 12

ACP and fentanyl

Fluanisone and fentanyl

Question 13

Receptor effects of opioids

Answer 13

Potentiate post synaptic potassium channels

Inhibit pre synaptic sodium channels

Question 14

Sodium channel blockers

Answer 14

Local anaesthetics

Lignocaine, bupivicaine, procaine, mepivicaine

Question 15

Fast onset local anaesthetics

Answer 15

Mepivicaine, lignocaine

Question 16

Local anaesthetics in order leading to highest duration, potency and protein binding.

Answer 16

Lowest - procaine, lignocaine, mepivicaine, bupivicaine - highest

Question 17

Two sedatives and their MOA

Answer 17

Xylazine, medetomidine, detomidine

Alpha 2 agonists - increase glycine in the spinal cord - muscle relaxation and analgesia

Question 18

Alpha 2 reversal

Answer 18

Atipamizole

Question 19

Minor tranquilizer MOA

Answer 19

Benzodiazepines potentiate GABAa receptors

Midazolam

Question 20

Oxazepam

Answer 20

Metabolite of midazolam, used as an appetite stimulant

Question 21

Benzodiazepine reversal

Answer 21

Reduce respiratory depression
Choral hydrate
Flumazenil

Question 22

Two classes of major tranquilizer

Answer 22

Phenothiazines

Butyrophenones

Question 23

ACP class and MOA

Answer 23

Phenothiazine

Acts upon d2 h1 a1 and muscarinic receptors

Question 24

Butyrophenone drug

Answer 24

Azaperone

Question 25

How can antiepileptics work?

Answer 25

Increase GABA

Decrease Glutamate