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Hematology Exam 1 > RBC Development > Flashcards

RBC Development Flashcards

0
Q

What are the functions of platelets?

A

Cellular fragments from megakaryocyte
Adhere & aggregate to a wound
Initiate coagulation cascade

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1
Q

What is the lifespan of a mature erythrocyte?

A

120 days

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2
Q

What is erythropoiesis?

A

RBC production

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3
Q

Where does erythropoiesis occur?

A

Axial skeleton

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4
Q

What is erythropoietin?

A

A growth factor hormone produced in the kidney

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5
Q

How are RBCs produced?

A

Red cell precursors divide into daughter cells that can also divide in 3 successive reductions

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6
Q

What are the sites of erythropoiesis in regards to age?

A

Prenatal 0-6 weeks: Yolk Sac
Prenatal 6-18 weeks: Liver
Prenatal 18-36 weeks: Spleen
Birth: Bone marrow

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7
Q

What is the ratio of myeloid cell precursors to erythroid cell precursors?

A

4:1

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8
Q

Where is the site for bone marrow collection?

A

Posterior superior iliac crest

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9
Q

Where does red cell maturation occur?

A

Bone marrow

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10
Q

Where is the most appropriate site for bone marrow collection in newborns & infants?

A

Upper end of the tibia

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11
Q

What cell do blood cells originate from?

A

Myeloid stem cell

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12
Q

List the red cell maturation sequence (RBC precursors)

A 
Pronormoblast
Basophilic Normoblast
Polychromatic Normoblast
Orthochromatic Normoblast
Polychromatic Erythrocyte
Erythrocyte
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13
Q

What is the first cell in the RBC precursor series?

A

Pronormoblast

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14
Q

What is the the size of a pronormoblast?

A

14-24 microns

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15
Q

What are some features of the nucleus and cytoplasm of a pronormoblast?

A

Large round reddish blue nucleus

Blue cytoplasm

16
Q

What are two distinguishing features of a pronormoblast?

A

Prominent nucleoli

Perinuclear halo

17
Q

What is the second cell in the RBC precursor series?

A

Basophilic normoblast

18
Q

What is the size of a basophilic normoblast?

A

12-17 microns

19
Q

What are some features of a basophilic normoblast?

A 
Coarsened chromatin
Nucleoli ill defined or absent
Mostly blue (RNA) cytoplasm
20
Q

What is the third RBC precursor in the series?

A

Polychromatic normoblast

21
Q

What is the size of a polychromatic normoblast?

A

10-15 microns

22
Q

What are some features of a polychromatic normoblast?

A

Cytoplasm has some pink due to hemaglobin presence & blue due to RNA

23
Q

What is special about a polychromatic normoblast?

A

It is the last precursor to be able to divide

24
Q

What is the fourth in the RBC precursor series?

A

Orthochromatic normoblast

25
Q

What are some features of an orthochromatic normoblast?

A

Solid blue black degenerated nucleus
Cytoplasm mostly pink
“Pkynotic”nucleus has no parachromatin
Cell cannot divide

26
Q

What is the fifth cell in the RBC precursor series?

A

Polychromatophilic erythrocyte “retic”

27
Q

What size is a polychromatophilic erythrocyte?

A

8-10 microns

28
Q

What are some features of a polychromatophilic erythrocyte?

A

Cell has bluish tint, mostly pink
Circulates 1-2 days while it matures
Frequently seen in blood of newborns
Increased number seen in hypoxia

29
Q

What are features of a mature erythrocyte?

A

7-8 microns, no nucleus

Pink cytoplasm

30
Q

What is a mature erythrocyte unable to synthesize?

A

Hemaglobin

31
Q

What is a reticulocyte?

A

Polychromatophilic erythrocyte

32
Q

What are two names for pronormoblast?

A

Proerythroblast

Rubriblast

33
Q

What are two names for basophilic normoblast?

A

Basophilic erythroblast

Prorubicyte

34
Q

What are two names for polychromatophilic normoblast?

A

Polychromatophilic erythroblast

Rubricyte

35
Q

What are two names for orthochromatic normoblast?

A

Orthochromatic erythroblast

Metarubricyte

36
Q

What are other names for a reticulocyte?

A

Polychromatophilic erythrocyte

Diffusely basophilic erythrocyte

Hematology Exam 1 (7 decks)

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