RBC Development Flashcards
What are the functions of platelets?
Cellular fragments from megakaryocyte
Adhere & aggregate to a wound
Initiate coagulation cascade
What is the lifespan of a mature erythrocyte?
120 days
What is erythropoiesis?
RBC production
Where does erythropoiesis occur?
Axial skeleton
What is erythropoietin?
A growth factor hormone produced in the kidney
How are RBCs produced?
Red cell precursors divide into daughter cells that can also divide in 3 successive reductions
What are the sites of erythropoiesis in regards to age?
Prenatal 0-6 weeks: Yolk Sac
Prenatal 6-18 weeks: Liver
Prenatal 18-36 weeks: Spleen
Birth: Bone marrow
What is the ratio of myeloid cell precursors to erythroid cell precursors?
4:1
Where is the site for bone marrow collection?
Posterior superior iliac crest
Where does red cell maturation occur?
Bone marrow
Where is the most appropriate site for bone marrow collection in newborns & infants?
Upper end of the tibia
What cell do blood cells originate from?
Myeloid stem cell
List the red cell maturation sequence (RBC precursors)
Pronormoblast Basophilic Normoblast Polychromatic Normoblast Orthochromatic Normoblast Polychromatic Erythrocyte Erythrocyte
What is the first cell in the RBC precursor series?
Pronormoblast
What is the the size of a pronormoblast?
14-24 microns
What are some features of the nucleus and cytoplasm of a pronormoblast?
Large round reddish blue nucleus
Blue cytoplasm
What are two distinguishing features of a pronormoblast?
Prominent nucleoli
Perinuclear halo
What is the second cell in the RBC precursor series?
Basophilic normoblast
What is the size of a basophilic normoblast?
12-17 microns
What are some features of a basophilic normoblast?
Coarsened chromatin Nucleoli ill defined or absent Mostly blue (RNA) cytoplasm
What is the third RBC precursor in the series?
Polychromatic normoblast
What is the size of a polychromatic normoblast?
10-15 microns
What are some features of a polychromatic normoblast?
Cytoplasm has some pink due to hemaglobin presence & blue due to RNA
What is special about a polychromatic normoblast?
It is the last precursor to be able to divide
What is the fourth in the RBC precursor series?
Orthochromatic normoblast
What are some features of an orthochromatic normoblast?
Solid blue black degenerated nucleus
Cytoplasm mostly pink
“Pkynotic”nucleus has no parachromatin
Cell cannot divide
What is the fifth cell in the RBC precursor series?
Polychromatophilic erythrocyte “retic”
What size is a polychromatophilic erythrocyte?
8-10 microns
What are some features of a polychromatophilic erythrocyte?
Cell has bluish tint, mostly pink
Circulates 1-2 days while it matures
Frequently seen in blood of newborns
Increased number seen in hypoxia
What are features of a mature erythrocyte?
7-8 microns, no nucleus
Pink cytoplasm
What is a mature erythrocyte unable to synthesize?
Hemaglobin
What is a reticulocyte?
Polychromatophilic erythrocyte
What are two names for pronormoblast?
Proerythroblast
Rubriblast
What are two names for basophilic normoblast?
Basophilic erythroblast
Prorubicyte
What are two names for polychromatophilic normoblast?
Polychromatophilic erythroblast
Rubricyte
What are two names for orthochromatic normoblast?
Orthochromatic erythroblast
Metarubricyte
What are other names for a reticulocyte?
Polychromatophilic erythrocyte
Diffusely basophilic erythrocyte
