Rash Flashcards
Dermatitis is also interchangeable with
Eczema
Non-infective inflammatory skin diseases that represent a reaction pattern to various stimuli
Dermatitis
All classifications of dermatitis produce clinical features:
Pruritic, erythematous lesions, indistinct lesions.
Atopic
Allergy
Atopic dermatitis
Immune system attacks the skin. Creases of the body and exposed skin surfaces
Atopic dermatitis
Allergen in the environment, may not happen with the first encounter.
To determine the body surface area that is erythematous, use
the rule of 9’s.
Causes of diffuse hyperpigmentation
Endocrine disease
Addison’s disease (excess ACTH)
Ectopic ACTH secretion (e.g. carcinoma)
The contraceptive pill or pregnancy
Thyrotoxicosis, acromegaly, phaeochromocytoma
Metabolic
Malabsorption or malnutrition
Liver diseases (e.g. haemochromatosis, primary
biliary cirrhosis, Wilson’s disease)
Chronic kidney disease
Porphyria
Chronic infection (e.g. bacterial endocarditis)
Connective tissue disease (e.g. systemic lupus,
scleroderma, dermatomyositis)
Racial or genetic
Other
Drugs (e.g. chlorpromazine, busulfan, arsenicals)
Radiation
Benign skin tumors
- Warts
- Molluscum contagiosum
- Seborrhoeic keratoses
- Dermatofibroma
- Neurofibroma
- Angioma
- Xanthoma
Malignant skin tumors
- Basal cell carcinoma
- Squamous cell carcinoma
- Bowen’s* disease (squamous cell carcinoma
confined to the epithelial layer of the skin—
carcinoma in situ) - Malignant melanoma (which can be metastatic—
see Figure 40.33) - Secondary deposits
Causes of facial flushing
- Menopause
- Drugs and foods (e.g. nifedipine, sildenafil,
monosodium glutamate [MSG]) - Alcohol after taking the drug disulfiram (or
alcohol alone in some people) - Systemic mastocytosis
- Rosacea
- Carcinoid syndrome (secretion of serotonin and
other mediators by a tumour may produce
flushing, diarrhoea and valvular heart disease) - Autonomic dysfunction
- Medullary carcinoma of the thyroid
Causes of erythroderma
- Eczema
- Psoriasis
- Drugs (e.g. phenytoin, allopurinol)
- Pityriasis rubra pilaris
- Mycosis fungoides, leukaemia, lymphoma
- Lichen planus
- Pemphigus foliaceus
- Hereditary disorders
- Dermatophytosis
- Toxic shock syndrome—generalised erythroderma
Causes of itchiness
- Asteatosis (dry skin)
- Atopic dermatitis (erythematous, oedematous
papular patches on head, neck, flexural surfaces) - Urticaria
- Scabies
- Dermatitis herpetiformis
Did the inside of your mouth become ulcerated
and painful suddenly?
Stevens-Johnson
syndrome;
Causes of hives
Acute viral infection—upper respiratory infection, viral hepatitis, infectious mononucleosis, mycoplasma
Acute bacterial infection—dental abscess, sinusitis
Food allergy (IgE mediated)—usually milk, egg, peanut, shellfish
Drug allergy (IgE mediated drug-induced urticaria)—often an antibiotic
Drug-induced urticaria due to pseudoallergy—aspirin, nonselective nonsteroidal anti-inflammatory drugs, opiates, radiocontrast media; these cause urticaria without immune activation
Vaccination
Bee or wasp stings
Widespread reaction following localised contact urticaria — for example, rubber latex