Random Things to remember (FINAL) Flashcards
What nerves both sympathetic and parasympathetic innervate the foregut?
Greater splanchnic - Sym (T5-T9)
Vagas - Para
What nerves both sympathetic and parasympathetic innervate the midgut?
Greater and Lesser splanchnic - Sym (T5-T11)
Vagas - Para
What nerves both sympathetic and parasympathetic innervate the hindgut?
Lumbar and Sacral Splanchnic - Sym
Pelvic splanchic - para
What percentage of atmosphere is O2?
about 21%
What is volume of shunted blood called that passes through the pulmonary circulation/min?
physiologic shunt
air that remains in the respiratory passages or arrives in alveoli that are not particularly perfused wiht blood is called what?
physiological dead space air
What portion of the lung has the highest VA/Q? meaning that is has less perfusion for the same amount of alveolar ventilation?
the upper part of the lung.
what is the average arterial partial pressure of oxygen as it leaves the lung?
95mm HG
what is the average arterial partial pressure of oxygen as it leaves the capillaries?
40mm Hg
What is a better way to deliver more oxygen to the tissues? increasing the partial pressure of O2 or increasing the amount of hemoglobin/RBCs?
increasing the amount of hemoglobin because it gives O2 something to bind to because it is not very soluble in blood
What molecule helps oxygen get off of hemoglobin more easily?
2,3 DPG
Which effects regarding the blood’s capacity to handle CO2 and O2 are worded the same but named differently?
haldane effect (Oxygenation of blood) and bohr effect (pH of blood)
what is the percent of water in plasma?
92%
What vitamin is essential for clotting in both the intrinsic and extrinsic pathways?
vitamin K
do allosteric enzymes follow MIchaelis-Menten kinetics?
no
Where do allosteric enzymes have allosteric substrates bind?
not to the active site even if it is homotropic regulation
do pacemaker cells like the SA and AV nodes have an absolute refractory period?
no
The strength of a cardiac muscle contraction is directly proportional to what?
the intracellular Calcium concentration
What is the bainbridge reflex?
it responds to changes in blood volume. Increases the heart rate when atrial pressure is high.
What is a First Degree AV block?
when the PR interval is longer than it should be
What is a Second Degree Type I AV block?
When the PR interval is cyclically lengthening until a QRS complex is dropped
What is a Second Degree Type 2 AV block?
When the PR interval is normal but you get random dropping of QRS complexes
What is a Third Degree AV block?
When you have atria and ventricles that are not in sync with each other. They are both irregular.
What is bulk flow?
movement of protein free extracellular fluid and water soluble substances in and out through water filled pores or intercellular clefts
Where does the largest pressure drop happen in the vasculature?
the arterioles. That does not mean it is the lowest pressure it just means that is where we see the biggest drop in pressure
Does glucose make a hemi acetal or hemiketal?
hemi acetal
does fructose make a hemi ketal or a hemi acetal?
hemi ketal
What are the two sugars that make up lactose?
galactose and glucose
What are the linkages between glucose molecules in cellulose?
Beta 1,4 linkages (we cannot break them down)
What re the linkages between glucose moleules in starch?
Alpha 1,4 glucose linkages
What typical histological layer is the Pharynx missing making it only have 3 layers instead of the typical four that the rest of the digestive system has?
missing the muscularis mucosa/submucosa
What is the first digestive organ that has the typical four histological layers?
esophagus
what two things released by the digestive system cause HCL secretion?
gastrin and histamine
What does ghrelin do?
cause a feeling of satiation
what does serotonin do?
gives pleasure when you eat
How much of HCL secretion is do to the brain sending signals preparing the body for food, (cephalic) and how much is controlled by gastric signalling?
30% cephalic
60% gastric
10% im not sure
which part of the small intestine is most responsible for the absorption of things?
jejunum
Which part of the small intestin is most responsible for chemical digestion?
duodenum
Which part of the small intestine is most responsible fore absorption of lipid micelles?
ileum
what do brunner’s glands secrete mostly?
mucus
What is the purpose Microfold (M) cells in the gut?
THey are specialized epithelial cells that sit over Peyer’s patches and work as antigen presenting cells to the immune cells in the Peyer’s patches
What is the purpose of enteroendocrine cells?
They are in charge of local and systemic signals relating to digestion and transit. They secrete things like CCK and Secretin and GIP and Peptide YY to cause things to happen in the gall bladder and pancreas
how are carbohydrates absorbed into the gut?
They are cotransported in the case of glucose with Sodium. Fructose however can just diffuse through the membrane
How do we get water to be absorbed in the gut?
we transport as much sodium into the intestinal cells as we can and then it draws the water into the cells because of osmosis
What does GIP (gastric inhibitory peptide) do?
stimulates insulin secretion by beta cells
what does peptide YY do?
signals long term satiety to the brain
What can superoxides and vitamin E do to help the body deal with free radicals that are formed?
They can accept the extra electron
name the 2 ways that ATP can be used for energy?
group transfer reaction
hydrolysis
what is the Mesovarium?
portion of the broad ligament around the ovary
What is the female equivalent of the bulbourethral glands?
the greater vestibular gland
What nerve innervates somatic sensation for the exterior third of the vaginal canal and the clitoris?
the pudendal nerve
From what spinal cord levels does the pudendal nerve arise?
S2-4
What two modalities are in the pudendal nerve?
Somatic sensory and Somatic Motor
What is the innervation that causes the clitoris to erect?
Parasympathetic - Pelvic Splanchnic nerves (S2-S4)
What does noncompetitve inhibition do to Vmax and Km?
it reduces Vmax and does nothing to Km
What does uncompetitive inhibition do to Vmax and Km?
reduces Vmax and Km moves to the left
What does mixed inhibition do to the Vmax and Km?
reduces Vmax and Km moves to the right
What nerve is responsible for sensing stimulation in the male sexual response?
Pudendal
What nerve is responsible for Erection in the male sexual response? Is it para or sympathetic?
Pelvic Splanchnic nerves (parasympathetic)
What nerves are responsible for the Emission phase of the male sexual response? Is it para or sympathetic?
Lumbar and Sacral Splanchnic nerves (sympathetic)
What nerve is responsible fore Ejaculation in the male sexual response?
Pudendal nerve (somatic)
What is the artery that goes through the copora cavernosa?
central artery of the penis
What causes constriction of the internal urethral sphincter?
Norepinephrine through the Lumbar and Sacral Splanchnic nerve innervation
What enzyme is critical for all endocytosis?
Rab GTPase
What signalling pathway does Epinephrine use? to cause what?
G-protein and PLC signalling to cause vasoconstriction via release of calcium
What signaling pathway does Insulin use? to cause what?
RTK and MAPK signaling to transcription of genes needed for cellular growth and division (this is the example he wanted us to know)
PI3K signalling to cause the inactivation of GSK3 which will cause glycogen synthase to be activated and thus glycogen will be synthesized
T/F: glucose is a molecular precursor to other things?
True: like amino acids
What is the point of regulation for glycogenesis?
glycogen synthase enzyme
Glycogen has what linkages between glucose molecules?
Alpha 1,4 linkages with alpha 1,6 branch points
What is the action of glucose 6 phosphatase and what is the only organ in which it is found?
only found in the liver. Glucose 6 phosphatase takes off the phosphate from G6P to make it just Glucose.
Is Phosphorylase enzyme active or inactive when phosphorylated? What metabolic signals cause it to be phosphorylated?
it is active when phosphorylated. Glucagon and epinephrine cause it to be phosphorylated so that it breaks down more glycogen.
What are the enzymes that are the points of regulation for glycolysis and gluconeogenesis?
PFK1 for glycolysis and
Frucose 1,6Bisphosphatase a.k.a. FBPase-1 for Gluconeeogenesis
What are the 4 enzymes involved in gluconeogenesis that are not invovled in glycolysis?
Glucose 6 phosphatase
Fructose 1,6 Bisphosphatase
PEP carboxykinase
Pyruvate Carboxylase
What are the input costs of Gluconeogenesis?
4 ATP
2 GTP
2 NADH + H+
What is the electron acceptor in Glycolysis and must be maintained for it to function?
NAD+
What are the net products of Glycolysis?
2 pyruvate
2ATP
2 NADH