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Question 1

mechanism of valvular damage in acute rheumatic fever

Answer 1

molecular mimicry occurring whereby IgG’s formed against the M protein of GAS cross react with specific cardiac proteins and thus damage the heart valves

HS II

Question 2

secondary bacteria

Answer 2

a result of infection at a distant site (such as lungs, kidney, soft tissue) leading to invasion of bacteria into the bloodstream

Question 3

bactericidal or bacteriostatic abx are used to tx endocarditis?

Answer 3

bactericidal

Question 4

phagocyte MOA

Answer 4

1. production of O2 free radicals via NADPH oxidase
2. release of intracellular antimicrobial peptides
3. release “nets” composed of degraded DNA and histones

Question 5

what serves to adhere the bacterium to the cell as the initial activation step for phagocytosis?

Answer 5

Integrins + complement receptors, lectins and Fc receptors

Question 6

type III secretion system

Answer 6

Salmonella, Shigella, EHEC, EPEC, Campylobacter and Yersinia.

Question 7

asymptomatic bacteriuria should generally not be treated except in the setting of

Answer 7

pregnancy or in patients undergoing urologic procedures

Question 8

organisms causing atypical pneumonia

Answer 8

Legionella
Mycoplasma
Chlamydia

Question 9

E. coli is most common cause of

Answer 9

urinary tract infections; and now the most common cause of meningitis in neonates

Question 10

Erisypelas

Answer 10

strep pyogenes

Question 11

obligate intracellular pathogens

Answer 11

Chlamydia trachomatis and Legionella pneumophila

Shigella, Rickettsiae, Salmonella, Yersinia enterocolitica, Chlamydia, Mycobacterium tuberculosis, Legionella pneumophila, Ehrlichia/Anaplasma.

Question 12

bacterial pathogens that are transmitted via respiratory droplets/aerosols

Answer 12

Bordatella pertussis, Legionella pneumophila

Neisseria meningitidis