Cell Wall Inhibitors I/II, DNA and Metabolic Toxins, Protein Synthesis Inhibitors Flashcards
b-lactams excretion
kidneys
early rxn to b-lactams
IgE
late rxn to b-lactams
- rash
- immune destruct wbc/rbc/platelets
- serum sickness (Fever, rash (morbilliform), arthritis, glomerulonephritis)
main use oxacillin
penicillinase-prod S. aureus
ampicillin uses
enterococcus
listeria
some gram - (H. influenza, some E coli, proteus)
dental prophylaxis
amoxicillin
covers meningitis secondary to listeria
ampicillin
amoxicillin + _____ = augmentin
clavulanate (beta-lactamase inhibitor)
good choice for diverticulitis (mixed flora)
b-lactams demonstrate ___-dependent killing
time
MSSA tx
oxacillin
cephalosporin excretion
renal
cephalosporin use in pt with penicillin allergy
can use in pt with LATE penicillin allergy (rash)
NEVER use in pt w/ hx of PCN anaphylaxis
skin/soft tissue infec
which cephalosporin gen
1st (Cefazolin)
activity against B fragilis
2nd gen (Cefoxitin)
T/F
ceftaroline cover psuedomonas
F