Pharm Nuggets

Question 1

penicillin resistant to b-lactamase degradation

Answer 1

antistaphylococcal penicillins

• oxacillin
• nafcillin
• dicloxacillin

Question 2

resistant to cleavage by most b-lactamases

Answer 2

carbapenems

Question 3

narrow spectrum b-lactam gram - only

Answer 3

aztronam

Question 4

generally, as cephalosporin generation increases, which coverages inc/dec?

Answer 4

gram - increases, gram + decreases

Question 5

cephalosporin with inc anaerobic coverage

Answer 5

2nd gen

• cefuroxime
• cefoxitine
• cefotetan

Question 6

cephalosporin with good CSF penetration

Answer 6

3rd gen

• ceftriaxone
• cefotaxime
• ceftazidme

Question 7

cephalosporin that binds PBP2a

Answer 7

5th gen

-ceftaroline

Question 8

red man syndrome

Answer 8

vancomycin

Question 9

skel m. toxicity

Answer 9

daptomycin

Question 10

antacids can bind up

Answer 10

quinolones

tetracyclines

Question 11

aminoglycosides have synergistic effects when added to

Answer 11

B-lactams

Question 12

P450 inhib

Answer 12

macrolides

Question 13

mainstay tx of tick-borne illnesses

Answer 13

tetracylines

Question 14

esophageal ulceration

Answer 14

tetracyclines

Question 15

particularly high rates of C. diff with use of

Answer 15

clindamycin

Question 16

serotonin syndrome

Answer 16

linezolid

Question 17

kernicterus

Answer 17

sulfonamides

Question 18

all of the protein synthesis inhibitors are bacterio___ while aminoglycosides are bacterio____

Answer 18

all protein synth inhibitors –> bacteriostatic (block prod of proteins)

aminoglycosides –> bactericidal

Question 19

big guns against MRSA

Answer 19

vancomycin
daptomycin
linezolid

Question 20

take a van to the metro when treating

Answer 20

C. diff

Question 21

only b-lactam against MRSA

Answer 21

ceftaroline (5th gen cephalosporin)

Question 22

which beta-lactam lowers the seizure threshold?

Answer 22

imipenem

Question 23

very broad b-lactam can cover pseudomonas

Answer 23

piperacillin

Question 24

respiratory quinolones

Answer 24

levofloxacin

moxifloxacin

Question 25

gram - (Pseudomonas)

Answer 25

- ceftazidime (3rd) - cefepime (4th) - aminoglycosides - ciprofloxacin - aztreonam - imipenem

Question 26

gram + (MRSA)

Answer 26

- vancomycin - linezolid - daptomycin - ceftaroline - doxycycline - SMX-TMR

Question 27

organisms that cause atypical pneumonia can be covered with which abx

Answer 27

fluoroquinolone (moxifloxacin) | macrolides

Question 28

Common bacterial causes of community acquired pneumonia

Answer 28

Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis

Question 29

organisms causing atypical pneumonia

Answer 29

Legionella Mycoplasma Chlamydia

Question 30

of all quinolones, which has most effects on gram -

Answer 30

ciprofloxacin | including pseudomonas

Question 31

Beta-lactams are not very active against ______ organisms - they require activiely replicating organisms and those that have a cell wall.

Answer 31

intracellular

Question 32

rarely used

Answer 32

Chloramphenicol

Question 33

protein synthesis inhibitor only active against gram positive organisms?

Answer 33

linezolid