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Question 1

What is bioavailability (F)?

Answer 1

Fraction of the administered dose of drug that reaches the systemic circulation.

Question 2

What is clearance?

Answer 2

Volume of plasma “cleared” of drug per unit time eg. Lh-1 or mlmin-1.

Question 3

What is a drug receptor?

Answer 3

A macromolecular component of a cell with which a drug interacts to produce a response. Usually a protein.

Question 4

What kind of drug receptor are there?

Answer 4

1) Enzyme linked. 2) Ion channel 3) GPCR 4) Nuclear (gene) linked

Question 5

What is affinity?

Answer 5

Measure of propensity of a drug to bind to its receptor; the attractiveness of a drug and receptor.

Question 6

What is efficacy?

Answer 6

Ability of a bound drug to change the receptor in a way that produces an effect; some drugs possess affinity but NOT efficacy.

Question 7

What drugs should you avoid prescribing to patients with renal disease?

Answer 7

Metformin and NSAIDs.