Random 3 Flashcards
What causes Lucke’s renal cell carcinoma in frogs?
Alloherpesvirus- ranid herpesvirus 1
Where does ranid alphaherpes 1 live and in what species?
Northern leopard frogs; renal convoluted tubules
Pathogenesis of ranid herpesvirus 1 renal adenocarcinoma
Infected when young, latent until 2years, renal carcinomas
Temperature dependent:
Summer- collagenase and metastasis
Winter- INIBs
MCF general histo observed
Kidney: Lymphoproliferation, vasculitis (fibrinoid necrosis), ulcerative mucocutaneous lesions
Bladder: hemorrhagic cystitis
What type of virus is MCF caused by?
Gammaherpesvirus
Characteristic gross lesions with MCF
Corneal edema, lymphadenopathy, exudative dermatitis, bladder hemorrhage
Where does canine herpesvirus go latent?
Trigeminal ganglia
Where does canine herpesvirus replicate?
Cerebellar granule neurons
Key histo with canine herpesvirus 1
Necrosis/hemorrhage in many organs; INIBs in epithelial cells
Key histo with cytomegalovirus (betaherpesvirus)
Cytomegaly, owl eye INIBs
Who gets amdoparvovirus?
Aleutian mink homozygous for aleutian gene or LYST gene defect (chediak higashi)
What do animals with Aleutian mink disease get clinically?
Type III hypersensitivity with ICGN and arteritis
What virus causes FIP?
alphacoronavirus
A weak cell mediated response to FIP is associated with
Type IV hypersensitivity and granulomas (dry)
A lack of cell mediated immunity to FIP is associated with
Type III hypersensitivity and effusion and hypergammaglobulinemia (wet)
Where does feline coronavirus replicate?
Within macrophages
Key histo for FIP
Pyogranulomatous to necrotizing phlebitis
Keratic precipitates
What causes canine distemper virus?
Morbillivirus
What cell receptors does canine distemper use?
CD150 (SLAM)
PVRL4 (nectin 4)
What virulence factors does canine distemper have?
Fusion proteins (F protein)
Attachment proteins (H protein)
Key histo of canine distemper in the urinary system?
INIBs and ICIBs in bladder/renal pelvis
What other systemic lesions are seen with canine distemper? (5)
Hard pad disease
Bronchointerstitial pneumonia
White matter demyelination
Enamel hypoplasia
Ocular inflammation
What causes budgerigar fledging disease?
Polyomavirus
Who is affected by nononcogenic BFDV?
Psittacines
What clinical sign is seen with BFDV?
Feather dystrophy
Key histo with BFDV
Hepatic necrosis
Membranous GN (type III hypersensitivity)
Karyomegaly and INIBs
Ultrastructure feature of polyomavirus
Paracrystalline arrays
Key histo features with polyomavirus in monkeys
Collecting tubule hypertrophy
Basophilic INIBs
What is Ovine herpesvirus-2 (OvHV-2)?
Sheep associated MCF
What do goats with MCF get?
Granulomatous mural folliculitis
Who gets sterile hemorrhagic cystitis that can progress to UCC?
Dogs treated with cyclophosphamide
Which tumor has a 50% metastasis rate?
Urothelial cell carcinoma
What tumors usually occur at the trigone?
Both UCC and botryoid rhabdomyosarcoma
What clin path findings characterize nephrotic syndrome?
Proteinuria, hypoalbuminemia, edema, hyperlipidemia
What causes nephrotic syndrome?
Amyloidosis
Leishmania
Glomerulonephritis/glomerulonephropathy
