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Question 1

What causes Lucke’s renal cell carcinoma in frogs?

Answer 1

Alloherpesvirus- ranid herpesvirus 1

Question 2

Where does ranid alphaherpes 1 live and in what species?

Answer 2

Northern leopard frogs; renal convoluted tubules

Question 3

Pathogenesis of ranid herpesvirus 1 renal adenocarcinoma

Answer 3

Infected when young, latent until 2years, renal carcinomas
Temperature dependent:
Summer- collagenase and metastasis
Winter- INIBs

Question 4

MCF general histo observed

Answer 4

Kidney: Lymphoproliferation, vasculitis (fibrinoid necrosis), ulcerative mucocutaneous lesions
Bladder: hemorrhagic cystitis

Question 5

What type of virus is MCF caused by?

Answer 5

Gammaherpesvirus

Question 6

Characteristic gross lesions with MCF

Answer 6

Corneal edema, lymphadenopathy, exudative dermatitis, bladder hemorrhage

Question 7

Where does canine herpesvirus go latent?

Answer 7

Trigeminal ganglia

Question 8

Where does canine herpesvirus replicate?

Answer 8

Cerebellar granule neurons

Question 9

Key histo with canine herpesvirus 1

Answer 9

Necrosis/hemorrhage in many organs; INIBs in epithelial cells

Question 10

Key histo with cytomegalovirus (betaherpesvirus)

Answer 10

Cytomegaly, owl eye INIBs

Question 11

Who gets amdoparvovirus?

Answer 11

Aleutian mink homozygous for aleutian gene or LYST gene defect (chediak higashi)

Question 12

What do animals with Aleutian mink disease get clinically?

Answer 12

Type III hypersensitivity with ICGN and arteritis

Question 13

What virus causes FIP?

Answer 13

alphacoronavirus

Question 14

A weak cell mediated response to FIP is associated with

Answer 14

Type IV hypersensitivity and granulomas (dry)

Question 15

A lack of cell mediated immunity to FIP is associated with

Answer 15

Type III hypersensitivity and effusion and hypergammaglobulinemia (wet)

Question 16

Where does feline coronavirus replicate?

Answer 16

Within macrophages

Question 17

Key histo for FIP

Answer 17

Pyogranulomatous to necrotizing phlebitis
Keratic precipitates

Question 18

What causes canine distemper virus?

Answer 18

Morbillivirus

Question 19

What cell receptors does canine distemper use?

Answer 19

CD150 (SLAM)
PVRL4 (nectin 4)

Question 20

What virulence factors does canine distemper have?

Answer 20

Fusion proteins (F protein)
Attachment proteins (H protein)

Question 21

Key histo of canine distemper in the urinary system?

Answer 21

INIBs and ICIBs in bladder/renal pelvis

Question 22

What other systemic lesions are seen with canine distemper? (5)

Answer 22

Hard pad disease
Bronchointerstitial pneumonia
White matter demyelination
Enamel hypoplasia
Ocular inflammation

Question 23

What causes budgerigar fledging disease?

Answer 23

Polyomavirus

Question 24

Who is affected by nononcogenic BFDV?

Answer 24

Psittacines

Question 25

What clinical sign is seen with BFDV?

Answer 25

Feather dystrophy

Question 26

Key histo with BFDV

Answer 26

Hepatic necrosis
Membranous GN (type III hypersensitivity)
Karyomegaly and INIBs

Question 27

Ultrastructure feature of polyomavirus

Answer 27

Paracrystalline arrays

Question 28

Key histo features with polyomavirus in monkeys

Answer 28

Collecting tubule hypertrophy
Basophilic INIBs

Question 29

What is Ovine herpesvirus-2 (OvHV-2)?

Answer 29

Sheep associated MCF

Question 30

What do goats with MCF get?

Answer 30

Granulomatous mural folliculitis

Question 31

Who gets sterile hemorrhagic cystitis that can progress to UCC?

Answer 31

Dogs treated with cyclophosphamide

Question 32

Which tumor has a 50% metastasis rate?

Answer 32

Urothelial cell carcinoma

Question 33

What tumors usually occur at the trigone?

Answer 33

Both UCC and botryoid rhabdomyosarcoma

Question 34

What clin path findings characterize nephrotic syndrome?

Answer 34

Proteinuria, hypoalbuminemia, edema, hyperlipidemia

Question 35

What causes nephrotic syndrome?

Answer 35

Amyloidosis
Leishmania
Glomerulonephritis/glomerulonephropathy