Random Flashcards
Entities causing hemoglobinuria
Copper toxicity in sheep
Zinc toxicity
Acer rubrum
Leptospirosis
Babesia
Stain for leptospirosis; location of leptospires
Warthin-Starry; PCT
Leptospirosis virulence factors
Invasive motility (flagella)
LPS
Len (leptospiral endostatin-like) proteins (LigA, Plasma factor H, LipL32)
Hemolysin
Biofilm
Where does Ehrlichia live?
Within monocytes
Causes of white spotted kidney in the dog
Canine herpesvirus 1 (puppies)
Leishmania spp.
Borrelia burgdorferi
Hepatozoon canis
Canine adenovirus 1
Causes of white spotted kidney in pigs
PRRSv
PCV2
Causes of white spotted kidney in cattle
Calves- e.coli, salmonella, brucells, lepto
Malignant catarrhal fever
Theileriosis
Lumpy skin disease
Cause of white spotted kidney in horses
Equine infectious anemia
Causes of white spotted kidney in sheep
Sheep pox
Small animal lentivirus (maedi-visna)
What breed has more severe Ehrlichia canis?
GSD
Morph in kidney with ehrlichiosis
Plamacytic nephritis
Glomerular amyloidosis
What unusual finding has been reported in canine leptospirosis?
Exudative glomerulonephritis
Clostridium perfrigens type D toxins
Alpha toxin
Epsilon toxin**- toxic to endothelium and tubular epithelium
Other organ affected in pulpy kidney disease
Brain (perivascular proteinaceous edema)
Salmon bacteria
Renibacterium salmoninarum
Most susceptible type of salmon to Renibacterium
Pacific
Most resistant type of salmon to Renibacterium
Atlantic
Histologic lesion with Renibacterium
Granulomas, macrophages contain coccobacilli
Key histo feature with erysipelothrix rhusiopathiae
Embolic nephritis
Pathology caused by Erysipelothrix (6 different systems)
Sepsis
Cutaneous
Polyarthritis
Endocarditis
Discospondyitis
Embolic nephritis
Cause of pyelonephritis in pigs
Actinobaculum suis
Erysipelothrix virulence factors
Neuraminidase
Capsular polysaccharide
Invasins
Surface proteins
SOD
Catalase
Morphologic characteristics of Candida
Narrow based budding yeast
Parallel wall, sepatate hyphae
Pseudohyphae
Aspergillus virulence factors
Beta glucan
Melanin
Ochratoxin A**- causes renal disease in pigs
Aspergillus morphologic features
Septate
Parallel walls
Dichotomous acute angle branching
Who gets Cloisonne kidney?
Goats
What do Basenjis get?
Fanconi-like syndrome (PCT disorder with paradoxical glucosuria)
What is the key histo finding with Fanconi-like syndrome?
Marked hypertrophy and karyomegaly of tubular epithelium
Key histo finding with Cloisonne kidney
Gray/brown pigmentation of BM of PCT
Key histo finding with membranous glomerulonephritis
Spikes and holes (subepithelial ICs)
Who gets membranous glomerulonephritis?
Cats
Who gets proliferative glomerulonephritis
Horses
Who gets membranoproliferative glomerulonephritis?
Hereditary in pigs
C3 deficiency in Finnish Landrace sheep and Brittany spaniels
Key histo findings with membranoproliferative GN?
Double-contoured BM “tram tracks” associated with intramembranous or subendothelial ICs
PTH effects on Ca/P
Increases Ca resorption, decreases P resorption
Increases bone resorption, decreases bone deposition
Overall, increases Ca, decreases P
Increases calcitriol (by increased 1alpha hydroxylase aka vit D production by kidney), thereby increased GI absorption of Ca and phos
Calcitriol effects on Ca/P
Increases Ca and Phosphorus overall
Increases bone resorption
Increases absorption of Ca and Phos in GI
Most common amyloid in domestic species
AA
What mice are resistant to AA amyloid?
A/J mice
What breeds get familial AA amyloidosis?
Shar pei (medullary)
Abyssinians (medullary, glomerular)
Siamese (liver, kidney)
Key histo findings in chronic progressive nephropathy (rats)
Chronic changes in all parts of nephron, metastatic mineralization (only in rats, not mice)
Rat breeds predisposed to chronic progressive nephropathy
Sprague-Dawley
Fischer 344
Key histo findings with diabetic nephropathy
Glomerulosclerosis
Glycogen change
Lipid emboli and fat vacuoles in mesangium
Key histo findings with glomerular lipidosis
Foam cells in mesangium (microvacuoles in cystoplasm)
Key histo finding in gout
Urate tophi (pathognomonic)
Key histo findings with renal dysplasia/progressive juvenile nephropathy (6)
Fetal glomeruli
Primitive mesenchyme
Blind ending collecting ducts
Persistent metanephric ducts
Adenomatoid epithelial proliferation
Osseous metaplasia (rare)
Who gets Gilbert syndrome (congenital hyperbilirubinemia)
Southdown sheep
Aspergillus virulence factors
Ochratoxin-A (causes renal dz in pigs)
Beta glucan
Melanin
Key histo findings with hypertensive arteriosclerosis
Glomerulosclerosis
Proliferative arteriosclerosis (onion skinning)
Hyaline arteriosclerosis
Who gets autosomal dominant polycystic kidney disease?
Bull terriers
Persian cats
Who gets autosomal recessive polycystic kidney disease?
West Highland and Cairn terriers
Perendale sheep
Autosomal dominant PCKD is linked to
PKD-1 and PKD-2 genes
Autosomal recessive PCKD is linked to
PKHD1 gene
Lab animal prone to renal congenital cysts
BALB/C mice
Key histo feature with Chediak-Higashi Syndrome
Large, PAS positive granules in leukocytes, platelets, hepatocytes, renal tubular epithelium, neurons, endothelial cells, melanocytes
Cause of Chediak-Higashi Syndrome
Autosomal recessive defect of LYST or Beige gene causes abnormal lysosomal trafficking
What histo finding occurs with Gilbert’s syndrome?
Progressive fibrosing interstitial nephritis
Cause of Gilbert’s syndrome
Type III photosensitization
What type of GN is associated with Borrelia? Other histo findings?
Membranoproliferative GN; tubular changes, lymphoplasmacytic interstitial nephritis
Where does leptospira interrogans hide?
PCT
Leptospirosis virulence factors
Invasive motility (flagella)
LPS
Len (Leptospiral endostatin-like) proteins (LigA, plasma factor H, LipL32)
Hemolysin
Biofilms
Key histo with lepto
Acute- Neutrophilic tubulointerstitial nephritis
Chronic- lymphoplasmacytic tubulointerstitial nephritis
Key histo with Ehrlichia canis
Plasmacytic nephritis***
Cytotoxic venom
Vipers
Neurotoxic venom
Elapids
Hemotoxic venom
Colubrids
Key histo with snake envenomation
Dilated and ruptured glomerular capillaries (mesangiolysis)
Tubular degeneration and necrosis
What is the toxin that causes acquired alpha mannosidosis?
Swainsonine
What plants have endophyte that produces swainsonine
Broomweed (Sida carpinifolia)
Astragalus
Oxytropis
Swainsona
Who gets alpha mannosidosis?
Angus, Murray, Galloway cattle
Persian cats
Who gets beta mannosidosis?
Salers cattle
Nubian goats
GSDs (MANBA gene defect)
Key histo with mannosidosis
Marked cytoplasmic vacuolation of PCTs
Normal finding in macaques
Syncytial cells in renal collecting tubules
Where does chronic polypoid cystitis occur?
Cranioventral wall of bladder
Who gets nephroblastomas?
Swine, chickens, fish
Cats and dogs less often
Paraneoplastic syndrome in dogs with nephroblastoma
polycythemia,
Tumor in german shepherd dogs
Ectopic nephroblastoma in thoracolumbar spinal cord of young dogs
Key histo features of nephroblastoma
Epithelial- blastemal cells
Mesenchymal- loose spindle cell stroma/ fibrous, mucoid, adipose, cartilage, bone
Primitive glomeruli
Abortive tubules
Renal cell carcinoma most common primary renal tumor in
Dogs, cattle, horses
RCC has a low metastatic rate in one species, which is it?
Cattle
What breed gets renal cyst/adeno- carcinoma and nodular dermatofibrosis due to mutation in Birt-Hogg-Dube gene?
GSD
RCC is virally induced by
Ranid herpesvirus-1
Avian erythroblastosis
What lab breed is predisposedto RCC ?
Longs-Evan (Eker) rats
What paraneoplastic syndromes does RCC cause?
Polycythemia; hypertrophic osteopathy if pulmonary metastasis
Infectious causes of ICGN in dogs
Canine adenovirus 1
Dirofilaria immitis
Borrelia burgdorferi
Leishmania infantum
Babesia gibsoni
What breed gets canine familial glomerulonephritis
Bernese Mountain dog
Infectious causes of ICGN in horses
Streptococcus equi
Herpesvirus
Equine infectious anemia
Infectious causes of ICGN in cats
Feline leukemia virus and hematopoeitic tumors
Noninfectious causes of ICGN
Heavy metal toxicosis (gold)
