Radioprotectors Flashcards
1
Q
What are the ideal properties of an ideal radioprotector?
A
preservation of the anti-tumor efficacy of radiation
2
Q
Any measure applied before the threshold dose for the specific side effects is reached?
A
Prophylaxis or protection
3
Q
What are the 4 Rs in the context of radioprotectors?
A
Reoxygenation
Repair (WR compound, amofostine)
Reassortment
Repopulation
4
Q
What chemical group is in radioprotectors?
A
free SH group
5
Q
Amofostine does it go to the normal tissue or to tumor?
A
Amofostine rarely goes to tumor, mainly goes to normal tissue
6
Q
Side effects of amofostine?
A
nausea, vomiting, GI effects
transient hypotension (in 60% of pts)
7
Q
Why is amofostine note widely used?
A
hypotension, with IMRT and protons less needed really
