Radiopharmaceuticals

Question 1

Maximum breakthrough activity of Mo-99 is

Answer 1

.15 uCi Mo-99 / mCi Tc-99m

Question 2

Maximum permissible level of aluminum in elucted Tc-99m

Answer 2

10 ug / ml

Question 3

Detection of alumina breakthrough can be determined using

Answer 3

chemical test kits

Question 4

Breakthrough of Mo-99 (740-780 keV γ) can be determined using

Answer 4

lead lined “moly shield”

Question 5

Radiopharmaceutical localization mechanisms (6)

Answer 5

1. Active transport such as thyroid uptake scanning with iodine.
2. Compartmental localization such as blood pool scanning with human serum albumin, plasma, or red blood cells.
3. Simple exchange or diffusion such as bone scanning with pyrophosphates.
4. Phagocytosis such as liver, spleen, and bone marrow scanning with radiocolloids.
5. Capillary blockade such as lung scanning with macroaggregate (8 to 75 mm) or organ perfusion studies with intraarterial injection of macroaggregates.
6. Cell sequestration such as spleen scanning with damaged red blood cells.

Question 6

Tc-99m pertechnetate may be taken up in

Answer 6

thyroid, salivary glands, and stomach as a result of its similarity to iodide and chloride ions

Question 7

¹²³I or ¹²³I-labeled hippuran is used to evaluate

Answer 7

kidney function

Question 8

A radioactive gas used in lung ventilation imaging

Answer 8

Xe-133

Question 9

^99mTc-MAG3 is replacing ______ for kidney function studies

Answer 9

hippuran

Question 10

Approximately 80% of NM use this isotope

Answer 10

Tc-99m

Question 11

Tc-HMPAO

Answer 11

Brain perfusion

Question 12

Tc-HMPAO labeled white blood cells

Answer 12

infection

Question 13

Tc-MAA

Answer 13

lung perfusion, intraarterial liver

Question 14

Tc-MAG3

Answer 14

Renal

Question 15

Tc-Sestamibi

Answer 15

Myocardial perfusion

parathyroid

breast

Question 16

Tc-Sulfur colloid

Answer 16

Liver / spleen

red bone marrow

esophageal transit

gastric emptying

Question 17

Krypton-81m gas

Answer 17

pulmonary ventilation

Question 18

Gallium 67 citrate

Answer 18

infection

tumor

Question 19

F-18 NaF

Answer 19

Bone Scan

Question 20

F-18 FDG

Answer 20

Brain metabolism

tumor

infection

cariac viability

Question 21

N-13 Ammonia

Answer 21

Cardiac pefusion

Question 22

C-11 Acetate

Answer 22

Prostate

Question 23

In-111 DTPA

Answer 23

CSF flow

gastirc liquid emptying

Question 24

In-111 labeled white blood cells

Answer 24

infection

Question 25

In-111 pentetreotide

Answer 25

somatostatin receptor tumors

Question 26

I-123 NaI

Answer 26

Thyroid

Question 27

I-123 MIBI

Answer 27

adrenal and neural crest tumors

Question 28

I-131 NaI

Answer 28

thyroid cancer

Question 29

Xe-127 or 133 Gas

Answer 29

lung ventilation

Question 30

Tl-201 Chloride

Answer 30

Myocardial perfusion

Question 31

Example of cappilary blockade

Answer 31

Macroaggregated albumin in lung

Question 32

Example of diffusion

Answer 32

Filtration of Tc DTPA by kidney

Question 33

Example of metabolism

Answer 33

FDG

Question 34

Example of active transport

Answer 34

Thallous ions in myocardium

Iodine in thyroid, salivary gland, stomach

iodocholesterol in adrenal scanning

Question 35

Example of compartmental containment

Answer 35

labeled red blood cells for gated blood pool studies

Question 36

Example of compartmental leakage

Answer 36

labeled red blood cells for detection of GI bleeding

Question 37

Example of physiochemical adsorption

Answer 37

phosphate bone-scanning agents

Question 38

Example of antibody-antigen reactions

Answer 38

tumor imaging w/ monoclonal antibodies