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Pharmacology > Radiopharmaceuticals > Flashcards

Radiopharmaceuticals Flashcards

1
Q

most radiopharmaceuticals used for

A

diagnostic

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2
Q

ideal half life for radiopharmaceutical

A

long enough to formulate and accomplish imaging, short enough to reduce radiation to patient

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3
Q

physical half life ideal relationship to biological half life

A

similar

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4
Q

ideal clearance of radiopharmaceuticals

A

rapid

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5
Q

ideal localization in target tissue

A

rapid

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6
Q

nuclear imaging

A

physiologic

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7
Q

85% nuclear medicine procedures agent

A

99m Tc

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8
Q

99m Tc parent

A

99Mo

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9
Q

doses produced every ____ of 99m Tc

A

24hrs

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10
Q

half life of 99m Tc

A

6 hrs, use within a few hours

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11
Q

thyroid scintigraphy agent

A

99mTcO4

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12
Q

thyroid scintigraphy compares

A

thyroid:salivary

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13
Q

hyperthyroid cat scintigraphy

A

more thyroid uptake than salivary

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14
Q

hypothyroid cat scintigraphy

A

no uptake

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15
Q

conditions diagnosed by thyroid scintigraphy

A

thyroid function, hyperplasia, adenoma, carcinoma

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16
Q

therapeutic radiopharmaceutical for thyroid

A

131I-

17
Q

normal liver

A

uniform uptake

18
Q

radiopharmaceutical used in liver imaging

A

sulfur colloid

19
Q

cancer appearance

A

irregular borders, abnormal morphology of liver, heterogeneous distribution, photopenic voids

20
Q

cirrhosis appearance

A

similar to cancer

21
Q

cirrhosis vs cancer

A

biopsy

22
Q

kidney scintigraphy

A

dynamic scan, DTPA

23
Q

kidney scintigraphy measures

A

GFR

24
Q

renal failure scan

A

low kidney signal, prolonged in blood

25
Q

bone imaging agent

A

MDP

26
Q

normal remodeling on bone scan

A

ends of long bones, mandible/maxilla

27
Q

PET scanner detects

A

photons traveling in opposite directions

28
Q

PET scan produces

A

3D high resolution image

29
Q

PET scan measure

A

quantify radioactivity

30
Q

PET scan agent

A

fluorodeoxyglucose

31
Q

FDG half life

A

2 hrs

32
Q

PET scan measures

A

glucose metabolism

33
Q

FDG trapped by

A

negative charge, not substrate for transport or metabolic enzyme

34
Q

FDG metabolized by

A

hexokinase

35
Q

combine PET with

A

CT

36
Q

determine if bone cancer treatable with radiopharmaceuticals

A

ratio of tumor:normal tissue uptake 3-4:1

37
Q

bone agent treatment

A

153Sm-EDTMP

38
Q

QuadraMet in humans

A

pain palliation

Pharmacology (7 decks)

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