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Pharmacology > Radiopharmaceuticals > Flashcards

Radiopharmaceuticals Flashcards

1
Q

most radiopharmaceuticals used for

A

diagnostic

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2
Q

ideal half life for radiopharmaceutical

A

long enough to formulate and accomplish imaging, short enough to reduce radiation to patient

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3
Q

physical half life ideal relationship to biological half life

A

similar

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4
Q

ideal clearance of radiopharmaceuticals

A

rapid

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5
Q

ideal localization in target tissue

A

rapid

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6
Q

nuclear imaging

A

physiologic

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7
Q

85% nuclear medicine procedures agent

A

99m Tc

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8
Q

99m Tc parent

A

99Mo

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9
Q

doses produced every ____ of 99m Tc

A

24hrs

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10
Q

half life of 99m Tc

A

6 hrs, use within a few hours

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11
Q

thyroid scintigraphy agent

A

99mTcO4

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12
Q

thyroid scintigraphy compares

A

thyroid:salivary

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13
Q

hyperthyroid cat scintigraphy

A

more thyroid uptake than salivary

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14
Q

hypothyroid cat scintigraphy

A

no uptake

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15
Q

conditions diagnosed by thyroid scintigraphy

A

thyroid function, hyperplasia, adenoma, carcinoma

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16
Q

therapeutic radiopharmaceutical for thyroid

17
Q

normal liver

A

uniform uptake

18
Q

radiopharmaceutical used in liver imaging

A

sulfur colloid

19
Q

cancer appearance

A

irregular borders, abnormal morphology of liver, heterogeneous distribution, photopenic voids

20
Q

cirrhosis appearance

A

similar to cancer

21
Q

cirrhosis vs cancer

22
Q

kidney scintigraphy

A

dynamic scan, DTPA

23
Q

kidney scintigraphy measures

24
Q

renal failure scan

A

low kidney signal, prolonged in blood

25
bone imaging agent
MDP
26
normal remodeling on bone scan
ends of long bones, mandible/maxilla
27
PET scanner detects
photons traveling in opposite directions
28
PET scan produces
3D high resolution image
29
PET scan measure
quantify radioactivity
30
PET scan agent
fluorodeoxyglucose
31
FDG half life
2 hrs
32
PET scan measures
glucose metabolism
33
FDG trapped by
negative charge, not substrate for transport or metabolic enzyme
34
FDG metabolized by
hexokinase
35
combine PET with
CT
36
determine if bone cancer treatable with radiopharmaceuticals
ratio of tumor:normal tissue uptake 3-4:1
37
bone agent treatment
153Sm-EDTMP
38
QuadraMet in humans
pain palliation

Pharmacology (7 decks)

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