radiology Flashcards
(110 cards)
what is an alpha particle composed of?
2 protons and 2 neutrons
how far can an alpha particle travel?
few inches
what is a beta particle composed of?
electron
how far can a beta particle travel ?
few feet
what is the difference between atoms and ions?
atoms have equal numbers of protons and electrons, ions do not
when radiation passes through matter, it ionises atoms and deposits energy locally, what is the approximate quantity of energy?
35eV
what is the most significant effect of ionising radiation ?
DNA damage - can be seen on faulty repair of chromosome breaks
radiation can damage DNA directly and indirectly - describe the direct effect
radiation interacts with atoms of a DNA molecule or other important cell components
radiation can damage DNA directly and indirectly - describe the indirect effect
radiation interacts with water in the cell producing free radicals which can cause damage
what are free radicals?
highly unstable high reactive molecules
which radiation usually is the cause of double strand breaks in DNA?
alpha
the biological effect of radiation will depend on a number of factors, list 4
type of radiation
amount
time over which dose is received
tissue or cell type irradiated
what is the effect of radiation dose on cell repair capacity?
low dose rate - less damaging and cells can repair
high dose rate - DNA repair capacity likely to be overwhelmed
which tissues are at higher risk of cancer following large radiation exposures?
oesophagus
thyroid
breast
tissue radio sensitivity is dependent on two factors which are
the function of the cells making up the tissue
if the cells are actively dividing
which type of cell are very radiosensitive?
stem cells - divide frequently
which cells are less sensitive to radiation?
differentiated as the do not divide
true or false
the more rapidly a cell is dividing, the more radiosensitive
true
give an example of highly radiosensitive tissue
bone marrow
lymphoid tissue
GI
give an example of moderately radiosensitive tissues
skin
lung
lens
which tissues are least radiosensitive
bone and cartilage
connective tissue
CNS
what are the 4 possible outcomes of radiation hitting the cell nucleus?
no change
dna mutation - repaired
dna mutation - cell death
dna mutation - cell survives but is mutated
what is the units of absorbed dose?
Gray Gy
what does absorbed dose measure?
the energy deposited by radiation