oral surgery Flashcards
how do you control pain during and after dental treatment?
local anaesthetic during procedure
systemic analgesic drugs post-op
name 3 NSAIDS?
aspirin
ibuprofen
diclofenac
what type of drugs are aspirin, diclofenac and ibuprofen?
NSAID
what type of drug is dihydrocodeine?
opiod used for analgesia
paracetamol, carbamazepine and dihydrocodiene are all used for what in dentistry?
analgesia
what must you know about a drug to prescribe it?
mechanism of action
doses
side effects
interactions
groups of patients to avoid
what are the four properties of aspirin?
1 analgesic
2 antipyretic (reduces fever)
3 anti inflammatory
4 metabolic
what is acetylsalicylic acid commonly known as?
aspirin
how are prostaglandins produced?
trauma and infection leads to phospholipid membrane breakdown producing arachidonic acid
arachidonic acid can be broken down to form prostaglandins
what is the function of prostaglandins?
they sensitise the tissues to other inflammatory products resulting in pain
do prostaglandins cause pain directly?
no they sensitise the tissues to other inflammatory products such as leukotrienes
true or false
increasing prostaglandin production will moderate the pain
false
correct answer - decreasing prostaglandin production will moderate pain
describe how the arachidonic acid pathway causes pain and inflammation
tissue injury causes injury to phospholipid cell membrane leading to release of arachidonic acid
arachidonic acid then follows the cyclooxygenase pathway to be broken down into prostaglandin which sensitises the tissues to pain and inflammation
what is the function of thromboxane?
platelet aggregation
what are the 4 products of the arachidonic acid pathway?
from the cyclooxgenase pathway -
prostacyclin
prostaglandin
thromboxane
from the 5 - lipoxygenase pathway
leukotrienes
what is the effect of leukotrienes?
broncho constriction
asthma attacks
smooth muscle contraction
arachidonic acid can be broken down into 4 products, what are they?
prostacyclin
prostaglandin
thromboxane
leukotrienes
how does aspirin reduce the production of prostaglandins?
inhibiting cyclo-oxygenases COX1 and COX2
which cyclooxygenase is aspirin more effective in inhibiting ?
COX1
how does analgesic action of aspirin result (refer to arachidonic acid pathway)?
inhibition of prostaglandin synthesis in inflamed tissues by cyclooxygenase inhibition
what effect does interleukin 1 have on the body?
temperature raising
how does aspirin affect interleukin 1?
prevents the temperature raising effects
reduces temperature in fever
does aspirin reduce normal temperature?
no
how does aspirin display antipyretic (anti fever) properties?
prevents temperature raising effects of interleukin 1