Radiation Protection Flashcards
What is a threshold dose relationship?
Some amount of radiation is required before a measureable effect can be detected
Linear: Constant slope
Curvilinear: non linear
Sigmoidal: s shaped
What is non threshold dose response relationship?
Non threshold
Any given amount of radiation will yield a measureable effect
No amount of radiation regardless of dose is safe
What is the law of Bergonie and Tribondeau?
Cell radio sensitivity increases with increased mitotic activity
Radio sensitivity decreases with maturity
Radio sensitivity decreases with increased specificity ex. Stem cells are more radio sensitive than nerve cells
What is OER? (Oxygen enhancement ratio)
Aerobic conditions enhance the effectiveness of radiation.
Increasing oxygen increases the cells sensitivity to radiation
What is LET?
Defines rate of energy deposited per unit track length through an absorber
Amount of radiation that is transferred to the body as the X-ray beam travels through the body
As LET increases, the quality factor for a given form of radiation will increase
LET is greases for alpha particles
As LET increases the probability of a cell’s survival and recovery…
decreases
What is fractionation?
equal doses of radiation that are delivered with time interval separations
What is protraction?
radiation dose that is delivered continously but at a lower dose rate
What is radiolysis?
radiation interaction with water
positive water molecules form free radicals
free radicals can combine to form hydrogen peroxide
What is the target theory?
If the master molecule of a cell is destroyed, the cell will die.
radiaion interactions with cells are random
What is interphase death?
also know as apoptosis
cell dies without attempting to divide
What is mitotic death?
cell goes through 1 or more mitotic phaes then dies
What is mitotic delay?
mitotic activity resumes after a short delay
What is reproductive failure?
cell does not die as a result of exposrue but loses ability to procreate
What is interference of function?
radiation exposure results in a temporary permanent interruption of cellular function.