RAAS

Question 1

What activates RAAS?

Answer 1

Hypovolaemia

Hypotension

Question 2

What is the role of the ANS?

Answer 2

Baroreceptor reflex
detects low blood pressure, responds
results in increased sympathetic tone

Question 3

What activates the kidneys?

Answer 3

Decreased renal perfusion
due to decrease in blood pressure

Increased sympathetic tone

Question 4

What do the kidneys do when activated?

Answer 4

Secrete more renin

Question 5

What is the role of the liver?

Answer 5

Secrete angiotensinogen into blood

Question 6

What type of secretion is involved in the liver secreting angiotensinogen?

Answer 6

Constitutive secretion

Question 7

What is the function of renin?

Answer 7

To cleave angiotensinogen into angiotensin 1

Question 8

What is the role of the lung endothelial cells?

Answer 8

Secrete angiotensin converting enzyme (ACE)

Question 9

What is the role of ACE?

Answer 9

Cleave angiotensin 1 into angiotensin 2

Question 10

What is the role of angiotensin 2?

Answer 10

Cause vasoconstriction

Stimulate adrenal cortex - to release aldosterone

Stimulate posterior pituitary - to release ADH

Question 11

What are the effects of aldosterone?

Answer 11

Increased expression of Na+ K+ pump
Increased reabsorption of Na+
Increased retention of water
Increased blood volume, blood pressure

Question 12

What are the effects of ADH?

Answer 12

Translocation of aquaporin channels

Question 13

What do aquaporin channels do?

Answer 13

Aid reabsorption of water back into blood