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7262 MS Block 1 > RA Pharmacotherapy > Flashcards

RA Pharmacotherapy Flashcards

1
Q

What does PQRSTA stand for?

A 
P - precipitating
Q - quality
R - region/radiating
S - severe
T - temporal
A - any associated Sx
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2
Q

What allergy is important for RA management?

A

sulfa

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3
Q

3 disease severity scales most common in US

A

CDAI
PAS
DAS

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4
Q

A ACR/EULAR score of ___ or higher is classified as definite RA

A

6

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5
Q

Early RA is < __ months

A

6

established RA is >= 6 months

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6
Q

Failure of __ or more synthetic DMARDS is poor RA prognosis

A

2

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7
Q

What is main goal of RA therapy?

A

complete disease remission or low disease activity

“treat to target”

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8
Q

__ is joint reconstruction or replacement

A

arthroplasty

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9
Q

__ is joint examination with possible removal of bone fragments or cartilage

A

arthroscopy

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10
Q

__ is bone or joint fusion

A

arthrodesis

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11
Q

Which drug class needs DEXA and FRAX assessment at regular monitoring interval?

A

corticosteroids

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12
Q

Which class can cause TB?

A

TNF alpha inhibitors

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13
Q

Abatacept dose for pt < 60kg?

A

500mg

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14
Q

Abatacept dose for pt 60-100kg

A

750mg

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15
Q

abatacept dose for pt > 100kg

A

1000mg every 2 weeks for 2 doses after the initial dose

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16
Q

Abatacept should not be given with what other drug class?

A

TNF alpha inhibitors

17
Q

Premedicate with what 3 things with rituximab?

A

diphenhydramine
glucocorticoid
acetaminophen

18
Q

DMARD monotherapy should be started within __ months of RA diagnosis

A

3

19
Q

What is preferred DMARD for early RA?

A

MTX

20
Q

What is preferred for combo therapies for mod to high RA?

A

synthetic DMARDs

21
Q

Monotherapy is ineffective for mod to high RA

a. true
b. false

A

a true

22
Q

Which is more effective for early RA?

DMARD (MTX) + biologic or biologic monotherapy?

A

DMARD (MTX) + biologic

23
Q

Can JAKi be used for early RA?

A

no

24
Q

Can all therapies be d/c for established RA?

A

no

25
Q

Avoid which RA drug class in HF pts?

A

TNF alpha inhibitors

26
Q

3 main high risk conditions for RA therapy?

A

CHF
Hep B/C
malignancies

27
Q

Which is preferred for pts with Hep C DMARDs or TNF alpha inhibitors?

A

DMARDs

28
Q

When should live vaccines be given to RA pts?

A

BEFORE DMARD therapy!!

killed vaccines (pneumococcal, IM influenza, hep B) and recombinant (HPV) can be given during therapy

29
Q

Two main leflunomide AEs?

A

hepatitis, jaundice

7262 MS Block 1 (11 decks)

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