Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

7262 MS Block 1 > RA/Gout Pathophysiology > Flashcards

RA/Gout Pathophysiology Flashcards

1
Q

What is most common SYSTEMIC inflammatory disease?

A

RA

occurs at any age and in pts of all races

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is most important genetic component for RA?

A

rheumatoid factor

autoantibody

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

2 HLA types important for RA?

A

DR1, DR4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

2 RA autoantibodies?

A 
Rheumatoid factor (RF)
anticitrullinated protein (ACPA)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

4 steps of RA pathophysiology:

A
  • genetic and environmental factors
  • autoimmune destruction of synovium and connective tissue
  • chronic inflammation of synovial tissue (pannus)
  • erosion of bone surface/cartilage
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is 2nd step of RA pathophys?

A

autoimmune destruction of synovium and connective tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is 3rd step of RA pathophys?

A

chronic inflammation of synovial tissue (pannus)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which condition has symmetrical joint involvement?

A

RA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What type of anemia might be present with RA?

A

normocytic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Joint pain/stiffness > ___ weeks is symptom of RA.

A

6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Cardiac manifestation of RA?

A

pericarditis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What phenomenon is an extra-articular manifestation of RA?

A

Raynaud’s phenomenon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

__ % of RA cases have rheumatoid nodules

A

20

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

4 pulmonary complications of RA?

A
  • pleural effusions
  • interstitial pneumonitis
  • pulmonary fibrosis
  • lung nodules
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

2 ocular/oral complications of RA?

A
  • keratoconjunctivitis sicca

- Sjorgren’s syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What syndrome involves splenomegaly and neutropenia that may be part of RA?

A

Felty’s syndrome

17
Q

What is most important risk factor for gout?

A

elevated serum urate

18
Q

Is RA more common in men or women?

A

women

19
Q

Is gout more common in men or women?

A

men

20
Q

Gout is an inflammatory joint disease due to deposition of what?

A

monosodium urate crystals

21
Q

Hyperuricemia is the accumulation of uric acid in the blood to >= __mg/dL

A

6.8

22
Q

Serum urate concentration levels > __mg/dL exceeds the solubility limit.

A

7

23
Q

2 uric acid excretion sources

A
  • urine (66%)

- GI tract (colonic bacteria)

24
Q

Enzymes:

Increased activity of ___ and decreased activity of ___ can lead to uric acid production.

A

phosphoribosyl pyrophosphate synthetase (PRPPase), hypoxanthine-guanine phosphoribosyltransferase (HGPRTase)

25
Q

Salicylates < __ g/day can cause hyperuricemia/gout

A

2

26
Q

2 most important drug classes that can cause hyperuricemia/gout?

A

diuretics

cytotoxic drugs

27
Q

Drugs that induce hyperuricemia and gout:

A
  • diuretics
  • salicylates (<2g/day)
  • cyclosporine
  • ethanol
  • nicotinic acid
  • cytotoxic drugs
  • levodopa
  • pyrazinamide
  • ethambutol
28
Q

4 parts of gout pathophys:

A
  • imbalance between uric acid production/elimination
  • accumulation of uric acid
  • formation of crystals in joints and surrounding tissue
  • acute inflammatory response - gout arthritis
29
Q

2 laboratory findings with gout

A
  • elevated serum uric acid

- leukocytosis

30
Q

Which type of gout is associated with monoarticular arthritis?

A

“podagra” classic gout

31
Q

which type of gout frequently attacks the first metatarsophalangeal joint?

A

“podagra” classic gout

joint is swollen and tender

32
Q

Which type of gout chronic monosodium urate crystals deposit in soft tissues?

A

tophaceous gout

soft tissue damage, deformity, joint destruction, nerve compression syndromes (carpal tunnel

33
Q

Which type of gout is similar to rheumatoid arthritis or osteoarthritis?

A

atypical gout

polyarthritis affecting any joint, upper or lower extremity

34
Q

Which type of gout causes nephrolithiasis and acute/chronic renal impairment?

A

gouty nephropathy

7262 MS Block 1 (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions