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BIOCHEM 332233 > R4eview > Flashcards

R4eview Flashcards

1
Q

Krebs cycle- location, main enzyme

A 
Mitochondrial matrix 
Isocitrate DH (iasm)
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2
Q

Pathways in the mitochondrial matrix

A

Krebs, ketogenesis, B-ox, prep step

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3
Q

Pathways in the inner mitochondrial matrix

A

ETS

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4
Q

Pathways in the extra cellular matrix

A

LPL

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5
Q

Cholesterol Synthesis- Location, enzyme

A

Cytosol, HMG CoA reductase

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6
Q

Fat synthesis- location, enzyme. Key thing that activates it and what does that inhibit

A

Cytosol, Acetly CoA carboxylase (ACC). Citrate actives it and inhibits isocitrate DH

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7
Q

Fat break down, intracellular enzymes. What strongly inhibits one of them?

A

ATGL, HSL, MGL. HSL is strongly inhibited by insulin

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8
Q

Hexokinase- Location, affinitiy for, Inhibited by

A

In most cells (muscle), locked in, high affinity for glucose (low kM) inhibited by G-6-P

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9
Q

Glucokinase- located where? Hight affinity for? Inhibits ?

A

Liver and B cells of pancreas, NOT inhibited by G-6-P, high Km, stimulated by insulin and fructose

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10
Q

ATP-PC system- location, enzymes

A

Cytosol and mitochondria, Creatine kinase.

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11
Q

Glyconeolysis- Location, enzymes. Stimulated by

A

Cytosol, glycogen phosphorylase. LOW energy

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12
Q

Glycogen synthesis. Most potent stimulator, location, enzyme

A

Cytoplasm, glycogen synthase, low glycogen levels, High energy

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13
Q

Ketogenesis- location, key enzyme,

A

Mitochondrial matrix, HMG CoA synthase

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14
Q

OHOT- location, enzymes, stimulates

A

Mitochondrial matrix, CPT1, glucagon low energy

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15
Q

Gluconeogenesis (GNG), location, inhibited by? Stimulated

A

Mitochondria and cytosol, ^fructose 2,6 bisphosphate. Stim- glucagon

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16
Q

What pathways are stimulated by HIGH energy (5)?

A

FA synthesis, cholesterol synthesis, glycogenesis, gluconeogenesis, DE novo synthesis

17
Q

What pathways are stimulated by INSULIN? (4)

A

Glycolysis, FA synthesis, Cholesterol synthesis, glycogenesis.

18
Q

What payways are stimulated by Glucogon? (4)

A

B-ox, keto, glycogenolysis, gluconeogenesis

19
Q

Stimulated by low energy (6)

A

Glycolysis, B ox, ETC, Krebs, Ketogenesis, glycogenolysis

20
Q

ALT is also known as? Glutamate gives aminos to pyruvate making what ?

A

GTP. Alanine

21
Q

What pathways are stimulated by HIGH energy (5)?

A

FA synthesis, cholesterol synthesis, glycogenesis, gluconeogenesis, DE novo synthesis

22
Q

What pathways are stimulated by INSULIN? (4)

A

Glycolysis, FA synthesis, Cholesterol synthesis, glycogenesis.

23
Q

What payways are stimulated by Glucogon? (4)

A

B-ox, keto, glycogenolysis, gluconeogenesis

24
Q

Stimulated by low energy (6)

A

Glycolysis, B ox, ETC, Krebs, Ketogenesis, glycogenolysis

25
Q

ALT is also known as? Glutamate gives aminos to pyruvate making what ?

A

GTP. Alanine

BIOCHEM 332233 (6 decks)

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