Alcohol Flashcards
Where does Alcohol dehydrogenase occur ?
Cytoplasm
Where does Acetaldehyde dehydrogenase take place?
Mitochondria
The liver first converts ethanol to acetaidehyde and then to acetate, both steps produces what?
NADH
Can alcohol dehydrogenase (ADH) or MEOS become saturated?
ADH
MEOS is associated with what?
Endoplasmic reticulum.
In the MEOS pathway does converting ethanol to acetaldehyde produce NADH?
NO!!!! It requires NADPH
Are some enzymes in the MEOS or alcohol HD pathway inducible?
MEOS
In the MEOS pathway does covering acetaldehyde to acetate produces NADH ?
Yes
What is 30 times more toxic than enthanol and gives you a hangover?
Acetaldehyde
An increase in NADH will do what to Krebs??
Inhibit it! (All dehydrogenases)
An increased aMOUNT of acetate results in what?
Increased acetyl CoA
Increased ketogenesis, acidity, fat synthesis.
ADH is inhibited
When acetaldehyde dehydrogenase is inhibited what happens?
Increased acetaldehyde
More NADH = less what?
Less fat burning, inhibits Krebs, GNG, retinoic acid.
More NADH = more what?
Fat synthesis and lactic acid
What enzyme turns pyruvate to lactate?
Lactate DH
