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BIOCHEM 332233 > Nucleotides > Flashcards

Nucleotides Flashcards

1
Q

Pyrimidines for DNA

A

Cytosine and thymine

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2
Q

Pyrimidines for RNA

A

Cytosine and uracil

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3
Q

De novo synthesis is made out of

A

Activated ribose (PRPP) + nitrogen from amino acids + ATP +CO2 ——> nucleotide

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4
Q

Salve pathway is made of what?

A

Activated ribose (PRPP) + base ———> new nucleotide

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5
Q

Gout is caused by what?

A

Accumulation of access URIA acid , hyperuricemia, accumulation of needle shaped crystals in soft tissue.

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6
Q

What is the final metabolic product of purine catabolism ?

A

Uric acid

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7
Q

In the de novo synthesis pathway purines start with what?

A

Start with PRPP. Build base on the ribose.

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8
Q

In the de novo synthesis pathway pyrimidines form from?

A

Base piece by piece and add to a ribose

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9
Q

What is known as activated Pentose

A

5-phosphoribosyl-1-pyrophosphate

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10
Q

De novo pathways form ribonucloties, what enzyme forms deoxyribonucleotides from a ribonucloties.

A

Ribonucleotide reductase

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11
Q

What is the location purine de novo synthesis

A

Liver cytosol

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12
Q

In de novo synthesis do purines utilize

ATP

A

Yes

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13
Q

What are nitrogen donors for purine synthesis

A

glycine, Asparatate, glutamine

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14
Q

Asparatate donates..

A

Nitrogen for purines and nitrogen and carbon for pyrimidines

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15
Q

Glutamine is a donor for….

A

Nitrogen for purines and nitrogen for pyrimidines

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16
Q

Glycine is a donor to…

A

Nitrogen for purines

17
Q

Bicarbonate is a donor for…

A

Carbon for pyrimidines

18
Q

Carbon dioxide is a donor for

A

Carbon for purines

19
Q

Folic acid (THF) is a donor for…

A

Carbon for purines and Carbon for pyrimidine

20
Q

What is not salvaged in humans but bacteria and some fungi can

A

Cytosine

21
Q

Degradation of purines. IMP- nucleoside and free base?

A

Inosine is the nucleoside

Hypoxanthine is the free base

22
Q

Degradation of purines. GMP- nucleoside and free base?

A

Nucleoside is guanosine

Free base is guanine

23
Q

Degradation of purines. AMP- nucleoside and free base?

A

Nucleoside is Adenosine

Free base is hypoxanthine

24
Q

What enzyme produces uric acid

A

Xanthine oxidase

25
Q

Does that a sense of HG-PRT stimulate de novo synthesis

A

Yes

26
Q

What enzyme is required for purine salvage pathway? And it’s derivatives?

A

PRT.

A-PRT is insignificant

HG-PRT

27
Q

What inhibits the committed step of de novo synthesis

A

Hypoxanthine, IMP, GMP, AMP.

28
Q

Pyrimidine de novo synthesis regulatory step is what’s?

A

Carbobamoyl pohosphate synthase (part of CAD)

29
Q

What inhibits

CAD?

A

UTP

30
Q

What stimulates CAD?

A

PRPP

31
Q

UTP——>CTP

Enzyme

A

CTP synthase

32
Q

Enzymes required for pyrimidine salvage pathway?

A 
Nucleoside phosphorylase (Pi) and 
Nucleoside kinase (+ADP)
33
Q

IMP—–>AMP uses what

A

GTP

34
Q

IMP——>GMP uses what?

A

ATP

BIOCHEM 332233 (6 decks)

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