QUIZ Antidepressants

Question 1

Describe the monoamine theory of depression and problems with this theory.

Answer 1

Mood related to 5-HAT NE and DA functioning

Depression is reduced level of above in those monoamine systems.

Question 2

Describe the glucocorticoid theory of Depression

Answer 2

Hypothalamic pituitary adrenal (HPA) axis:

• Hierarchy
• Stress starts in hypothalamus
• Negative feedback loop

Question 3

Name the three drug classes of antidepressants within the first and second generation antidepressants with one example of each

Answer 3

1. MAOIs
   EX: Phenelzine
2. TCAs
   EX: nortriptyline
3. SSRIs & SNRIs
   EX:

Question 4

Name three of the third generation of antidepressants and their mechanism of action.

Answer 4

1. Prozac
   it blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin
2. Zoloft
   helps correct the chemical imbalance of serotonin in the brain.
3. Paxil

Paroxetine potently and selectively inhibits neuronal serotonin reuptake through antagonism of the serotonin transporter

Question 5

Describe the serotonin syndrome

Answer 5

Serotonin syndrome occurs when you take medications that cause high levels of the chemical serotonin to accumulate in your body.

Serotonin syndrome can occur when you increase the dose of such a drug or add a new drug to your regimen.

Question 6

What is the effect of antidepressants on sleep..

Answer 6

MAOI insomnia or sedation
TCA bad dreams
SSRI and NSRI reduce REM
Fluoxetine increase vividness of dreams

Question 7

Describe the effects of antidepressant withdrawal

Answer 7

TCA Restlessness, anxiety, chills, akathesia

SSRI dizziness, light headedness, insomnia, fatigue, anxiety, nausea, HA and sensory disturbances

SNRI body symptoms heart palpitations and nusea and delusions