Quiz 8 Flashcards
Pharmokinetics
The process of drug movement to achieve drug action.
- absorption
- distribution
- metabolism(bio transformation)
- excretion
Pharmaceutic phase
Dissolution, disintegration
- breakdown of the medicine before the step of absorption.
Absorption (pharmacokinetic)
The movement of drug particles from the GI to body fluids by passive absorption, active absorption, or pinocytosis.
Distribution (pharmacokinetic)
The process by which the drug becomes available to the body fluids and tissues.
Metabolism or bio transformation
Pharmacokinetic
The process by which the body inactivates or bio transforms drugs.
-the liver is the main site of metabolism
Excretion or elimination
Pharmacokinetic
The main route of drug elimination is through the kidneys(urine) other routes include: feces, lungs, saliva, sweat, and breast milk.
Creative clearance
Test used to determine renal function. The test compares the level of creatinine in the urine with the level of creatinine in the blood.
-Lowe values are expected in older adults and females due to less muscle mass.
Onset of action
The time it takes to reach the minimum effective concentration after a drug is administered.
Peak Action
Occurs when the drug reaches it’s highest blood or plasma concentration.
Duration of Action
The length of time a drug has a pharmacological effect
Free drugs
Only free drugs are active and can cause a pharmacologic response
Protein Bound
The portion of the drug that is bound is inactive because it is not available to receptors and the portion that remains unbound is free,active drug
Dose response
The relationship between the minimal versus the maximal amount of drug dose needed to produce the desired drug response.
Receptor theory
Drugs act through receptors by binding to the receptor to produce(initiate) a response or to block(prevent) a response.
Agonist
Drugs that produce a response
