Quiz 4 flashcards
What are the 5 different types of Leukocytes (WBC’s)?
-Neutrophils
-Eosinophils
-Basophils
-Lymphocytes
-Monocytes
What are the characteristics and functions of Neutophils?
CHARACTERISTICS:
-50-70% of total leukocyte count
-stains that are chemically neutral (neither acidic nor basic)
-nucleus has a distinct lobed appearance and have 2-5 lobes
-polymorphonuclear/nucleus with many forms
FUNCTION:
-responders to the site of infection and are efficient phagocytes with a preference of bacteria
-granules:
-lysozymes
-oxidants (hydrogen peroxide)
-defensins that are proteins that bind to and puncture bacterial and fungal plasma membranes
What are the characteristics and functions of Eosinophils
CHARACTERISTICS:
-2-4% of total leukocyte count
-stain best with an acidic stain known as eosin
-nucleus has 2-3 lobes and granules will have a distinct red to orange color
FUNCTION:
-granules include antihistamine molecules and counteract activities of histamines, inflammatory chemicals produced by basophils and mast cells
-toxic to parasitic worms
-high counts are typical of patients experiencing allergies, parasitic worm infestations, and some autoimmune diseases
What are the characteristics and functions of basophils
CHARACTERISTICS:
-less than 1% of total leukocyte count
-stain best with basic (alkaline) stains
-contain large granules that pick up a dark blue stain intensify the inflammatory response
FUNCTION:
-share traits with mast cells
-release histamines, which contribute to inflammation
-release heparin, which opposes blood clotting
-high counts are associated with allergies, parasitic infections, and hypothyroidism
What are the characteristics and functions of Lymphocytes
CHARACTERISTICS:
-only formed element of blood that arises from lymphoid stem cells
-20-30% of all leukocytes
-high lymphocyte counts are characteristic of viral infections
-3 major groups are: natural killer cells, B cells, and T cells
What are Natural killer cells (NK cells)
They recognize cells that do not express “self” proteins on their plasma membrane or that contain foreign or abnormal markers
What are B cells (plasma cells)
-Produces the antibodies or immunoglobulins
-humoral (body fluid) immunity
What are T cells
-They provide cellular-level immunity by physically attacking foreign or diseased cells
What are the characteristics and function of Monocytes
CHARACTERISTICS:
-originate from myeloid stem cells
-2-8% of the total leukocyte count
-indented or horseshoe-shaped nuclei
FUNCTION:
-Surround and kill microorganisms
-ingest foreign material
-remove dead cells
-boost immune responses
-release antimicrobial defensins and chemotactic chemicals that attract other leukocytes to the site of an infection
What is hemopoiesis/hematopoiesis?
The process or blood replacement by the body
BEFORE BIRTH:
-liver
-spleen
-lymphatic tissue
-red bone marrow
AFTER BIRTH:
-red bone marrow
-cranial and pelvic bones
-vertebrae
-sternum
-proximal epiphyses of femur and humerus
What are 3 hemopoietic growth factors
-Erythropoietin
-Thrombopoietin
-Cytokines
What are Erythropoietin
-Secreted by kidneys in response to low oxygen levels
-prompts the production of erythrocytes
-athletes use synthetic EPO as a performance enhancing drug (blood doping) to increase RBC counts
What are Thrombopoietin
-Produced by the liver and kidneys
-triggers development of megakaryocytes into platelets
What are Cytokines
-Colony-stimulating factors (CSF’s)
-trigger the differentiating of myeloblasts into granular leukocytes, namely neutrophils, eosinophils, and basophils
-Interleukins
-signaling molecules important in hemopoiesis
What are the 4 types of anemia and their causes
SICKLE CELL
-genetic disorder caused by production of an abnormal type of hemoglobin called hemoglobin S
IRON DEFICIENCY
-most common
-insufficient iron available to allow production of sufficient heme
VITAMIN-DEFICIENT
-Megaloblastic anemia: Vit B12 deficiency and/or folate
-Pernicious anemia: Poor B12 absorption
THALASEMIA
-an inherited blood disorder characterized by less oxygen-carrying protein (hemoglobin) and fewer red blood cells in the body than normal.
What is the role of iron and B12 in blood?
IRON: allows the production of heme (a molecule that helps bind oxygen and iron in the blood stream)
B12: Forms red blood cells and DNA
What is the role/function of the kidneys in blood production
The kidneys secrete erythropoietin and produce thrombopoietin
What is the difference between anemia, thrombocytopenia, and leukemia
ANEMIA:
-when there is a lack of red blood cells or there are dysfunctional red blood cells leading to reduced oxygen flow to the body
THROMBOCYTOPENIA:
-blood may not clot properly, and excessive bleeding may result
LEUKEMIA:
-cancer involving an abundance of leukocytes
-Chronic leukemia is when mature leukocytes accumulate and fail to die
-Acute leukemia is when there is an overproduction of young, immature leukocytes
What are immunoglobulins
They are gamma globulins/antibodies and are produced by B cells (plasma cells) in response to exposure to antigens
What is the difference between oxygen rich and oxygen poor blood
OXYGEN RICH BLOOD: left side of the heat pumps blood from the lungs to the rest of the body (oxygenated blood)
OXYGEN POOR BLOOD: right side of the heart pumps oxygen rich blood from the body to the lungs to receive oxygen (non-oxygenated blood)
What are the layers of the heart wall
-Epicardium (outermost layer)
-Myocardium (middle layer)
-Endocardium (innermost layer)
what is the pericardium
It directly surrounds the heart and defines the pericardial cavity
What are the 4 valves of the heart and their functions
-Tricuspid valve: allow blood flowing into the heart from body to flow to the right ventricle to get pumped to lungs for oxygen
-Pulmonary valve: pick up oxygen to deliver to body
-Mitral valve: keep blood flowing in the right direction
-Aortic valve: keep blood flowing in the right direction through heart
What are the 5 great vessels of the heart
-inferior vena cava
-superior vena cava
-pulmonary arteries
-pulmonary veins
-root of the aorta
What is the path of blood flow through the heart
R.T.R.P.P.P.L.P.L.B.L.A.A.S
- Right atrium
- tricuspid valve
- right ventricle
- pulmonary semilunar valve
- pulmonary trunk
- pulmonary arteries
- lungs
- pulmonary veins
- left atrium
- bicuspid valve
- left ventricle
- aortic semilunar valve
- aorta
- systemic circulation
what is the chordae tendinae and its function
it is where the flab of the valve is attached and its function is to maintain the position and tension of the atrioventricular valves (tricuspid and bicuspid valve)
What is the papillary muscles function
-connect each of the flaps that extends from the inferior ventricular surface
-three papillary muscles in the right ventricle:
-anterior, posterior and septal
-correspond to the three sections of the valves
What is the function of the interventricular septum
it separates the two ventricles and allows for proper blood flow through the heart
What are the 4 chambers of the heart and their function
-RIGHT ATRIUM AND LEFT ATRIUM (upper chambers) :acts as a receiving chamber
-RIGHT VENTRICLE and LEFT VENTRICLE (lower chambers): serve as the primary pumping chambers
What are the 7 coronary arteries
-LEFT AND RIGHT CORONARY ARTERIES
-EPICARDIAL CORONARY ARTERIES
-CIRCUMFLEX CORONARY ARTERIES
-LEFT ANTERIOR DESCENDING ARTERY (LAD)
-MARGINAL ARTERIES
-POSTERIOR DESCENDING ARTERY
What is the function of the left and right coronary arteries
to supply blood to your heart
What is the function of the epicardial coronary artery
Branches that remain on the surface of artery and follow the sulci
What is the function of the circumflex arteries
-rises from the left coronary artery and follows the coronary sulcus to the left
-fuse with the small branches of the right coronary artery
What is the function of the left anterior descending artery
Interconnect with the branches of the posterior intercentricular artery, forming anastomoses