Quiz 4 Flashcards
meropenem 1
Brand: Merrem
Class: Carbapenem
Indication: Intra-abd infections, bacterial meningitis in peds, SSTIs
meropenem 2
MOA: Inhibits bacterial cell wall synthesis by binding to PBPs, eventually leading to cell lyses
BBW: N/A
Side Effects: Nausea, HA, pain
ertapenem 1
Brand: INVanz
Class: Carbapenem
Indication: Acute pelvic infections, CAP, intra-abs infections, SSTIs, UTI, ppx of surgical site infection in colorectal surgery
ertapenem 2
MOA: Inhibits bacterial cell wall synthesis by binding to PBPs, eventually leading to cell lyses
BBW: N/A
Side Effects: Diarrhea
valacyclovir 1
Brand: Valtrex
Class: Antiviral Agent, Oral
Indication: Herpes zoster (shingles); genital herpes; chickenpox, herpes labialis (cold sores)
valacyclovir 2
MOA: inhibits DNA synthesis and viral replication by competing with deoxyguanosine triphosphate for viral DNA polymerase and being incorporated into viral DNA
BBW: N/A
Side effects: abd pain, nausea, HA
valganciclovir 1
Brand name: Valcyte
Class: Antiviral Agent
Indication: CMV
valganciclovir 2
MOA: Metabolized to ganciclovir which competitively inhibits the binding of deoxyguanosine triphosphate to DNA polymerase resulting in inhibition of viral DNA synthesis
BBW: Granulocytopenia, anemia, thrombocytopenia
SE: N/V/D, graft rejection, tremor, retinal detachment, cough, upper respiratory infection, fever
acyclovir 1
Brand name: Zovirax
Class: Antiviral Agent
Indication: Treatment of genital herpes simplex virus (HSV) and HSV encephalitis
acyclovir 2
MOA: Acyclovir triphosphate inhibits DNA synthesis and viral replication by competing with deoxyguanosine triphosphate for viral DNA polymerase and being incorporated into viral DNA.
BBW: N/A
Side effects: malaise
dapsone 1
Brand name: Aczone
Class: Topical Skin Product, Acne
Indication: topical treatment of acne vulgaris
dapsone 2
MOA: Not well understood, but has anti-inflammatory and immunomodulatory effects
BBW: N/A
SE: Dryness, redness, oiliness, peeling of skin
ritonavir 1
Brand name: Norvir
Class: Antiretroviral, Protease Inhibitor (Anti-HIV)
Indication: HIV
ritonavir 2
MOA: Binds to the site of HIV-1 protease activity and inhibits, resulting in the formation of immature, noninfectious viral particles
BBW: Coadministration with sedative hypnotics, antiarrhythmics, or ergot alkaloid preparations may result in potentially serious and/or life-threatening adverse reactions
Side effects: raised serum cholesterol, N/V/D, altered taste, asthenia
atazanavir 1
Brand name: Reyataz
Class: Antiretroviral, Protease Inhibitor (Anti-HIV)
Indication: HIV-1 infections
atazanavir 2
MOA: Binds to the site of HIV-1 protease activity and inhibits cleavage of viral Gag-Pol polyprotein precursors into individual functional proteins required for infectious HIV. This results in the formation of immature, noninfectious viral particles.
BBW: N/A
Side effects: rash, abdominal pain, N/V/D, increased bilirubin, HA, cough, fever
lopinavir + ritonavir 1
Brand name: Kaletra
Class: Antiretroviral, Protease Inhibitor (Anti-HIV)
Indication: HIV
lopinavir + ritonavir 2
MOA: Lopinavir- binds to site of HIV-1 protease activity and inhibits cleavage of viral Gag-Pol polyprotein precursors into individual functional proteins required for infectious HIV, resulting in immature, noninfectious viral particles
Ritonavir- inhibits CYP3A metabolism of lopinavir, allowing increased levels of lopinavir
BBW: N/A
Side effects: increased serum cholesterol/TG, N/V/D
