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Blood Banking (BIOL 380) > Quiz 3 > Flashcards

Quiz 3 Flashcards

0
Q

Who typically requires an antibody identification test?

A
  • *Transfusion patient
  • *OB patient
  • *Donors
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1
Q

What is the purpose of antibody identification?

A

To detect unexpected or atypical antibody in the serum or on the cells that may cause in vivo destruction of red blood cells

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2
Q

What variations do antibody identification tests have?

A

Variations in temperature and media of reactivity

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3
Q

What factors influence antibody frequency?

A
  1. Antigen frequency
  2. Immunogenicity of antigen
  3. Presence of non-human antigen source similar to blood antigen
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4
Q

What antibody is most frequently found?

A

Anti-D

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5
Q

What are the alleles for the Lewis system?

A

Le(a)

Le(b)

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6
Q

What are the main alleles in the Kell system?

A

K, k

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7
Q

What are the main alleles in the Duffy system?

A

Fy(a+b-), Fy(a-b+), Fy(a+b+), Fy(a-b-)

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8
Q

What are the alleles found in the Kidd system?

A

Jk(a)

Jk(b)

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9
Q

What are the alleles of the P system?

A

P(1)
P(2)
p(k)
p(Tja-neg)

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10
Q

If an antibody reacts well in saline and at room temperature, what class of antibody is it most likely?

A

IgM

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11
Q

If an antibody reacts well at 37C in albumin or after antiglobulin test, what class of antibody is it usually?

A

IgG

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12
Q

What antibody can cross the placenta?

A

IgG

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13
Q

What antibody system reacts in all temperatures and mediums?

A

Lewis system

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14
Q

What antibodies deteriorate in storage?

A

P, Le(a), Fy(a), Kidd

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15
Q

What antibodies are destroyed by enzymes?

A

Duffy, MNSs

16
Q

What antibodies are enhanced by enzymes?

A

Rh, Kidd, Lewis, I, P

17
Q

What antibodies show dosage?

A

MNSs, Kidd, Rh, Duffy

18
Q

What antibodies are classified as IgM?

A 
Le(a), Le(b)
P
MN
I, i
ABO
19
Q

What antibodies are classified as IgG?

A 
D, C, E, c, e 
Jk(a), Jk(b)
k, K
S, s
Fy(a), Fy(b)
20
Q

How do you perform an autoabsorption?

A

Patient cells + Patient serum allows for antibodies to be absorbed out of the serum. Then use absorbed serum to test for antibodies.

21
Q

Procedure used for elution in antibody identification?

A

Removal of antibodies from red cells; then use eluate to identify the antibody

22
Q

Lewis system

  1. Function
  2. Optimal temperature
  3. Antibody type
  4. Specific media
A
  1. Affects if you are a secretor or not
  2. 25C
  3. IgM
  4. Saline
23
Q

Kell system

  1. Antibody class?
  2. Possible causes?
  3. Optimal temperature?
  4. Optimal medium?
A
  1. IgG
  2. Transfusion reactions & HDN
  3. 37C
  4. Anti-human globulin
24
Q

Duffy system

  1. Common in patients with…
  2. Antibody class?
  3. Possible causes?
  4. Optimal temperature?
  5. Optimal medium?
A
  1. Multiple transfusions
  2. IgG
  3. Transfusion reactions and HDN
  4. 37C
  5. Anti-human globulin
25
Q

The Duffy system has a relationship with what virus?

A

Plasmodium vivax –> malaria

26
Q

Kidd system

  1. Antibody class?
  2. Found in patients with…
  3. Possible causes?
  4. Optimal temperature?
  5. Optimal media?
A
  1. IgG
  2. Multiple transfusions
  3. Transfusion reactions and HDN
  4. 37C
  5. AHG
27
Q

MNSs system

1. List the antibodies found in this system

A
  • Anti-M
  • Anti-N
  • Anti-S
  • Anti-s
28
Q

Anti-M

  1. Antibody class?
  2. Important feature?
A
  1. IgM

2. Pronounced dosage effect

29
Q

Anti-S and anti-s

  1. Antibody class?
  2. Possible causes?
  3. Show dosage?
  4. Optimal temperature?
  5. Optimal medium?
A
  1. IgG
  2. Transfusion reactions and HDN
  3. Yes
  4. 37C
  5. AHG
30
Q

Anti-M and Anti-N

  1. Optimal temperature?
  2. Optimal medium?
A
  1. 25C

2. Saline

31
Q

P system

  1. Antibody class?
  2. Optimal temperature?
  3. Optimal media?
  4. Transfusion reactions and HDN?
A
  1. IgM
  2. 25C
  3. Saline
  4. No
32
Q

I, i system

  1. What antigen is found on normal adult red cells?
  2. What antigen is found on normal baby red cells?
A
  1. I

2. i

33
Q

Anti-I

  1. Causes problems with…
  2. Antibody class?
  3. Optimal temperature?
  4. Optimal media?
  5. Possible diseases?
A
  1. Reverse type, antibody screen, and cross match
  2. IgM
  3. 25C
  4. Saline
  5. Cold autoimmune hemolytic anemia

Blood Banking (BIOL 380) (5 decks)

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