Quiz 2

Question 0

What is the second most important blood group in transfusion?

Answer 0

Rh blood group

Question 1

What type of antibody is produced when RH (+) blood is transfused into a RH (-) patient?

Answer 1

Alloantibody

Question 2

What antigens are the most important in the Rh blood group system?

Answer 2

D, E, c, C, e

Question 3

Rh antibody

1. Class of antibody?

Answer 3

First appears as an IgM then switches to IgG

Question 4

What antibodies can cause hemolytic disease of the newborn and hemolytic transfusion reactions?

Answer 4

Antibodies to D, C, c, E, e

Question 5

What antibodies frequently show dosage?

Answer 5

Anti-c and anti-E

Question 6

What are the common symptoms of Rh D?

Answer 6

• Chills
• Fever
• Shock
• HDN

Question 7

What is the cause of hemolytic disease of a newborn?

Answer 7

IgG antibody passes through placenta to fetus and can cause fetal death

Question 8

What is the optimal temperature of reactivity for an Rh antibody?

Answer 8

37 C

Question 9

What is the optimal media of reactivity for Rh antibodies?

Answer 9

Albumin or anti-human globulin

Question 10

Fisher-Race

1. Theory of inheritance

Answer 10

Rh antigen derived from three pairs of closely linked genes and passed as a gene concept (CDE) with rare crossover

Question 11

Weiner

1. Theory of inheritance

Answer 11

1. Inherit one gene that controls the entire Rh system and expression of 8 alleles

Question 12

Tippet

1. Theory of inheritance

Answer 12

1. Based on two closely linked genes on chromosome 1

Question 13

What is the current Rh theory of inheritance?

Answer 13

Tippet

Question 14

What is the nomenclature for Rh 1 (Rosenfield) in terms of…

1. Weiner
2. Fisher-Race

Answer 14

1. Rh(o)

2. D

Question 15

What is the nomenclature for Rh 2 (Rosenfield) in terms of…

1. Weiner
2. Fisher-Race

Answer 15

1. rh’

2. C

Question 16

What is the nomenclature for Rh 3 (Rosenfield) in terms of…

1. Weiner
2. Fisher-Race

Answer 16

1. rh’’

2. E

Question 17

What is the nomenclature for Rh 4 (Rosenfield) in terms of…

1. Weiner
2. Fisher-Race

Answer 17

1. hr’

2. c

Question 18

What is the nomenclature for Rh 5 (Rosenfield) in terms of…

1. Weiner
2. Fisher-Race

Answer 18

1. hr’’

2. e

Question 19

D(u)

1. Definition

Answer 19

Weak form of the D antigen

Question 20

D(u)

1. Causes

Answer 20

• Heredity – less or altered D antigen on a cell
• Mosaic D
• Gene interaction - C in transposition to D (DCe/dCe)
• Genes independent of the Rh system can modify Rh expression

Question 21

What test do you perform to detect D(u)?

Answer 21

1. Indirect antiglobulin test

Question 22

What can you interpret if D(u) is (+) and control is (-)?

Answer 22

Rh (+)

Question 23

What can you interpret if D(u) is (+) and control is (+)?

Answer 23

Rh cannot be interpreted

Question 24

What are some Rh typing problems?

Answer 24

1. Weak or mixed field reactions
2. Positive autocontrol
3. Nonautoantibody to antigen (antibody to preservative)

Question 25

What causes a false (+) reaction in Rh typing?

Answer 25

1. High protein –> rouleaux
2. (+) DAT
3. Autoantibody
4. Anti-caprylate

Question 26

What causes a false (-) in Rh typing?

Answer 26

1. Rh hemolytic disease of a newborn

Question 27

What is the nomenclature in Fisher-Race?

Answer 27

C, c, C(w), E, e, D, D(u), d

Question 28

What is the nomenclature in Weiner?

Answer 28

R(c), R(1), R(2), R(z), r, r’, r’’, r(y)