Quiz 2 Flashcards
What are the 4 major cardiovascular diseases?
-Ishemic Heart Disease (MI), Hypertension, HF, and CVD (stroke)
What is the leading cause of death in the US?
-Heart disease
What is the outer layer of coronary arteries called?
-Adventitia
What is the adventitia formed by?
-collagen fibers
What is the basic support structure of the coronary arteries?
-The adventitia
What is the term for the blood supply to arterial walls?
-Vaso Vasorum
What is the name of the middle layer of coronary arteries?
-Media
What is the media composed of?
-Several layers of smooth muscle and an elastic membrane
What is the media of coronary arteries responsible for?
-Making adjustments to lumen diameter
What is the inner most layer of coronary arteries called?
-The intima
What is the intima composed of?
-Endothelial layer, basement membrane, smooth muscle cells, elastic and collagen fibers
Lipoprotiens and fibrinogen is most likely to accumulate in what layer of coronary arteries?
-The Intima
What two layers are on each side of the media?
-Internal and External elastic lamina
What are the 3 basic rules of fluid dynamics for myocardial perfusion?
- Fluid flow from an area of high pressure to low pressure
- Fluids follow the path of lest resistance
- if there is a blockage, the surrounding vessel will dilate to allow flow around the blockage
What are the 4 major determinants of myocardial blood flow?
- Diastolic BP
- Vasomotor tone
- Resistance to flow
- Left Ventricular end-diastolic pressure
What is the primary driving force for moving blood into myocardial tissue?
-Diastolic BP
What determines the volume of blood passed along to myocardial tissue?
-Vasomotor tone
A decrease in vasomotor tone will do what to the amount of blood passed along to myocardial tissue?
-It will increase it
What normally causes increased resistance to flow in myocardial tissue?
-Atherosclerosis
What is an atherosclerosis made up of?
-lipids and thrombus
Exposure of what leads to platelet aggregation and the formation of a thrombus?
-Endothelial layer
What is a hallmark sign of of advanced atherosclerosis?
-Hyperplasia of intimal smooth muscle
What gender is more likely to had CAD?
-Males, until 55 y/o then it is equal
What is the best predictor of a persons risk of CAD?
-Ratio of total cholesterol to HDL
What is considered low for HDLs?
-50 mg
What is considered high for triglycerides?
-150
BP greater than what presents you with a risk for CAD?
-140/90
BMI greater than what increases risk for CAD?
-30
What mainly causes sudden cardiac death?
-ventricular tachycardia or fibrillation
Why does ventricular fibrillation cause sudden cardiac death?
-The fluttering will not allow blood to be ejected from the ventricles
For those already diagnosed with CHF, an ejection fraction less than what increases a persons risk for sudden cardiac death?
-35%
What are the classical signs of stable angina?
-Tightness or pressure anywhere above the waist
Where can pain from angina radiate?
-Neck, arms and between the shoulder blades
When do symptoms develop and diminish with stable angina?
-develop with exertional activity and deminish with rest
What do women tend to complain of with unstable angina?
-indigestion, and pain between shoulder blades
What may diabetics present with with with stable angina?
-SOB