Quiz 2 Flashcards
Describe the mechanism of Idoxuridine-Thymidine analog in treating feline herpes virus-1
irreversible inhibits specific DNA polymerases (prevents viral replication)
Acyclovir is activated in herpes infected cells due to the presence of what viral encoded enzyme?
Thymidine kinase
Describe how oseltamivir (Tamiflu) works
metabolized by liver to release a metabolite that inhibits neuraminidase. prevents virion binding and thus slows virus spreading so immune system can overtake the infection
Poxviridae family: what type of virus (RNA or DNA) and where does it replicate?
DNA virus
cytoplasm
When some intracellular mature virions required an additional double-layered envelope derived from host cell membranes, referred to as _______ _______ ______
intracellular enveloped virus (IEV)
This virus infects a wide range of species; lesions resemble those of cowpox; can also be used as a recombinant virus vector for vaccination
Vaccinia virus
This virus commonly effects the teats of milking cows; it can also infect cats that hunt rodents (as they are the wild reservoir)
Cowpox
Virus that can affect cattle teats and be cause lesions on human hands and forearms called “milker’s nodules”
Pseudocowpox
Infection with this zoonotic virus is usually subclinical but cattle develop lesions in buccal cavity and on the muzzle
Bovine papular stomatitis
______________ is a zoonotic parapoxvirus that primarily affects young sheep causing chronic ulcerative lesions of the muzzle.
Orf virus
‘_________________ is defined as a virus that is maintained in nature through biological transmission between vertebrate hosts by hematophagous arthropods. These viruses replicate in the tissues of the insect.
Arbovirus
____________ are the most significant poxviruses of domestic animals as they cause high mortality in young animals and notable economic loss.
Sheeppox and goatpox
______________ causes a disease, considered foreign to the United States, associated with circumscribed skin nodules in cattle. Bos taurus cattle are more susceptible to this disease than Bos indicus cattle.
Lumpy skin disease virus
This virus is transmitted between swine by the pig louse and disease usually goes unrecognized
swinepox
_____ virus infects domestic chickens and turkeys and causes proliferative skin lesions and diptherritic lesions in the upper digestive and respiratory tracts
Fowlpox
Poxviruses are associated with _________ inclusions
intracelluar
_________________ is an oncogenic poxvirus that causes benign cutaneous fibromas in some rabbits though commonly associated with lethal infections of European rabbits.
Myoxma virus
__________ virus, which causes mousepox, can cause rapid death or chronic ulcerating lesions of the feet, tail, and snout of mice.
Ectromelia virus (mousepox)
Herpes viruses are DNA or RNA viruses? Where do they replicate?
DNA
Nucleus
During a latent infection with herpesvirus, the viral genome is maintained within the nucleus of the cell as a ________________________.
circular episomal element
Which subfamily of herpes viruses contains the majority of herpesvirus pathogens?
Alphaherpesvirinae
Disease caused by Bovine herpesvirus 2
Pseudo-lumpy skin disease
Ovine herpesvirus 2 (OvHV-2) causes what clinical disease in sheep?
does NOT cause clinical disease in sheep;
Causes malignant catarrhal fever in cattle and bison
Infection with this herpes virus in swine can cause abortions, mummified fetuses, and stillborn piglets; infection may also be subclinical (NOT zoonotic)
Suid herpesvirus 1 (pseudorabies)
Which equine herpes viruses are associated with viral rhinopneumonitis and abortion?
1 & 4
4(abortions are slightly more sporadic than with 1)
