Quiz 2

Question 1

Describe the mechanism of Idoxuridine-Thymidine analog in treating feline herpes virus-1

Answer 1

irreversible inhibits specific DNA polymerases (prevents viral replication)

Question 2

Acyclovir is activated in herpes infected cells due to the presence of what viral encoded enzyme?

Answer 2

Thymidine kinase

Question 3

Describe how oseltamivir (Tamiflu) works

Answer 3

metabolized by liver to release a metabolite that inhibits neuraminidase. prevents virion binding and thus slows virus spreading so immune system can overtake the infection

Question 4

Poxviridae family: what type of virus (RNA or DNA) and where does it replicate?

Answer 4

DNA virus

cytoplasm

Question 5

When some intracellular mature virions required an additional double-layered envelope derived from host cell membranes, referred to as _______ _______ ______

Answer 5

intracellular enveloped virus (IEV)

Question 6

This virus infects a wide range of species; lesions resemble those of cowpox; can also be used as a recombinant virus vector for vaccination

Answer 6

Vaccinia virus

Question 7

This virus commonly effects the teats of milking cows; it can also infect cats that hunt rodents (as they are the wild reservoir)

Answer 7

Cowpox

Question 8

Virus that can affect cattle teats and be cause lesions on human hands and forearms called “milker’s nodules”

Answer 8

Pseudocowpox

Question 9

Infection with this zoonotic virus is usually subclinical but cattle develop lesions in buccal cavity and on the muzzle

Answer 9

Bovine papular stomatitis

Question 10

______________ is a zoonotic parapoxvirus that primarily affects young sheep causing chronic ulcerative lesions of the muzzle.

Answer 10

Orf virus

Question 11

‘_________________ is defined as a virus that is maintained in nature through biological transmission between vertebrate hosts by hematophagous arthropods. These viruses replicate in the tissues of the insect.

Answer 11

Arbovirus

Question 12

____________ are the most significant poxviruses of domestic animals as they cause high mortality in young animals and notable economic loss.

Answer 12

Sheeppox and goatpox

Question 13

______________ causes a disease, considered foreign to the United States, associated with circumscribed skin nodules in cattle. Bos taurus cattle are more susceptible to this disease than Bos indicus cattle.

Answer 13

Lumpy skin disease virus

Question 14

This virus is transmitted between swine by the pig louse and disease usually goes unrecognized

Answer 14

swinepox

Question 15

_____ virus infects domestic chickens and turkeys and causes proliferative skin lesions and diptherritic lesions in the upper digestive and respiratory tracts

Answer 15

Fowlpox

Question 16

Poxviruses are associated with _________ inclusions

Answer 16

intracelluar

Question 17

_________________ is an oncogenic poxvirus that causes benign cutaneous fibromas in some rabbits though commonly associated with lethal infections of European rabbits.

Answer 17

Myoxma virus

Question 18

__________ virus, which causes mousepox, can cause rapid death or chronic ulcerating lesions of the feet, tail, and snout of mice.

Answer 18

Ectromelia virus (mousepox)

Question 19

Herpes viruses are DNA or RNA viruses? Where do they replicate?

Answer 19

DNA

Nucleus

Question 20

During a latent infection with herpesvirus, the viral genome is maintained within the nucleus of the cell as a ________________________.

Answer 20

circular episomal element

Question 21

Which subfamily of herpes viruses contains the majority of herpesvirus pathogens?

Answer 21

Alphaherpesvirinae

Question 22

Disease caused by Bovine herpesvirus 2

Answer 22

Pseudo-lumpy skin disease

Question 23

Ovine herpesvirus 2 (OvHV-2) causes what clinical disease in sheep?

Answer 23

does NOT cause clinical disease in sheep;

Causes malignant catarrhal fever in cattle and bison

Question 24

Infection with this herpes virus in swine can cause abortions, mummified fetuses, and stillborn piglets; infection may also be subclinical (NOT zoonotic)

Answer 24

Suid herpesvirus 1 (pseudorabies)

Question 25

Which equine herpes viruses are associated with viral rhinopneumonitis and abortion?

Answer 25

1 & 4

4(abortions are slightly more sporadic than with 1)