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Cology 2 Exam 1 > Quiz 2 > Flashcards

Quiz 2 Flashcards

1
Q

What is the effect of the following drugs on the activity of glutamate receptors (don’t worry about subtype)? (1 pt each)

  1. Ethanol Increase / decrease / no effect
  2. Pentobarbital Increase / decrease / no effect
A

Decrease

Decrease

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2
Q

What is the effect of the following drugs on the activity of GABA-A receptors (don’t worry about subtype)? (1 pt each)

  1. Phenobarbital Increase / decrease / no effect
  2. Ethanol Increase / decrease / no effect
A

Increase

Increase

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3
Q
  1. Which GABA-A receptor subunit is necessary for the sedative actions of phenobarbital? (1 pt)
    Alpha / gamma-2 / delta
A

Alpha

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4
Q

What is the effect of the following drugs on the activity of GABA-A receptors (don’t worry about subtype)? (1 pt each)

  1. gamma-hydroxy-butyrate Increase / decrease / no effect
  2. Ethanol Increase / decrease / no effect
  3. Thiopental Increase / decrease / no effect
A

No effect
Increase
Increase

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5
Q

3A) Pentobarbital increases the activity of GABA-A receptors. (1 pt) True / False

A

True

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6
Q

4A) Ethanol increases the activity of GABA-A receptors. (1 pt) True / False

A

True

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7
Q

7B) Ethanol decreases the activity of glutamate receptors? (1 pt) True / False

A

True

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8
Q

8B) Pentobarbital decreases the activity of glutamate receptors? (1 pt) True / False

A

True

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9
Q

9B) Alcohol dehydrogenase activity follows Zero / First order kinetics while acetaldehyde

	 dehydrogenase activity follows  Zero / First  order kinetics.  (2 pts)
A

Zero

First

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10
Q

Drinking ethanol before taking a dose of theophylline increases / decreases the

 	metabolism of theophylline.  On the other hand, theophylline metabolism is 

	increased / decreased in alcoholic patients.  (2 pts)
A

Decreases

Increased

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11
Q

Which of the following drugs increases the activity of GABA-A receptors? (answer yes or no, 1 pt each)

  1. Buspirone Yes No
  2. Ethanol Yes No
A

No

Yes

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12
Q

Which of the following drugs decreases the activity of glutamate receptors? (answer yes or no, 1 pt each)
(1 pt each)

  1. Ethanol Yes or No
  2. Buspirone Yes or No
A

Yes

No

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13
Q

The following drugs exhibit pharmacokinetic tolerance with repeated daily use. (1 pt each)

  1. Ethanol True / False
A

True

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14
Q
  1. Ethanol use acutely (increases, decreases) the metabolism of drugs by CYP2E1, but inan alcoholic, metabolism of drugs by this enzyme is (increased, decreased). (2 pts)
A

Decreases

Increased

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15
Q

At what doses of Barbituates could we use the following to block barbituate action?

Bicuculline
Picrotoxin

A

Bicuculline - low doses only (barbs can open GABA channels themselves at high doses, so this antagonist wouldn’t work)
Picrotoxin - high doses only (able to get in channel to impair flow)

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Cology 2 Exam 1 (14 decks)

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