Non-benzo anxiolytics Flashcards
How do 5HT-1A partial agonists work? How long do they take to work?
Work mostly at presynaptic receptors (act as an agonist or antagonist depending on serotonin levels)
Decreases serotonin and dopamine transmission
Anxiolytic actions take weeks to develop fully
Could possibly require up/down regulation of serotonin receptors
Benefits of 5HT-1A partial agonists over BDZ’s?
Adverse effects?
No sedation, less interaction with other sedatives
No tolerance or withdrawal
Adverse effects: Dizziness, restlessness, nausea, headache, seizures
Can 5HT-1A agonists be used with BDZ’s?
Yes in Generalized anxiety disorder (synergistic effect)
Can 5HT-1A agonists be used with SSRI’s?
Yes in Mixed anxiety/depression (synergistic effect)
5HT-1A agonists are not useful in what disorders
Panic disorder, social phobias, OCD, PTSD
What are examples of 5HT-1A partial agonists
Buspirone
Gepirone
How does Buspirone work
5HT-1A partial agonist
Decrease 5-HT and dopamine transmission
Anxiolytic without sedation
Takes weeks!
How does Gepirone work
5HT-1A partial agonist
Decrease 5-HT and dopamine transmission
Anxiolytic without sedation
Takes weeks!
How does Ondansetron work?
5-HT3 antagonist
Works post-synapticly, directly blocks 5-HT transmission
Which drug class is only effective for performance anxiety?
Beta blockers
Decreases anxiety-induced sympathetic activation
How does Clonidine work?
Anxiolytic that decreases norepinephrine release via autoreceptor activation
Works at Presynaptic receptors
How do CCK antagonists work?
They are non-peptide analogs
That’s all she gave us lol
How does Oxytocin work?
Decreases ethanol withdrawal-induced anxiety
Given intranasally
