Individual BDZ agents

Question 1

Zolpidem

Answer 1

Sleep disorders

Binds alpha1 ONLY

Question 2

Zaleplon

Answer 2

Binds alpha-1 only, sedation

Question 3

Eszopiclone

Answer 3

Binds alpha-1 only, sedation

Question 4

Indiplon

Answer 4

Binds alpha-1 only, sedation

Question 5

Clobazam

Answer 5

Binds alpha 2 subunits only
Used for Lennox-gastaut syndrome (seizures in children)
Less sedative/cognitive effects

Question 6

Bretazenil

Answer 6

Full agonist for alpha 5
Antagonist at alpha 1
Anxiolytic and anticonvulsant, very little sedative effects

Question 7

Imidazenil

Answer 7

Full agonist for alpha 5
Antagonist at alpha 1
Anxiolytic and anticonvulsant, very little sedative effects

Question 8

Loreclezole

Answer 8

Selective for receptors containing beta-2 subunit

Can also stimulate GABA-A receptor in the absence of GABA

Question 9

Buspirone

Answer 9

5-HT1A partial agonists, anxiolytic (takes weeks to work)

Question 10

Gepirone

Answer 10

5-HT1A partial agonist, anxiolytic (takes weeks to work)

Question 11

Ondansetron

Answer 11

5-HT3 antagonist

Question 12

Clonidine

Answer 12

Decreases norepinephrine release via autoreceptor activation

Question 13

Oxytocin

Answer 13

Decreases ethanol withdrawal-induced anxiety

Question 14

Nitrazepam

Answer 14

Selective anticonvulsant

Question 15

Nordazepam

Answer 15

Selective anticonvulsant