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Quiz 1 Flashcards

1
Q

What stays in the bloodstream better?

A

Hydrophilic

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2
Q

what crosses the blood-brain barrier better?

A

Lipophilic and non-ionized/uncharged

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3
Q

Bioavailability of IV, IM, SL

A

1

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4
Q

qualities of drug to pass sublingually

A
  • Lipophilic

- Ionized

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5
Q

what characteristic to cross the skin barrier

A

lipophilic

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6
Q

how does tempurature effect topical absorption?

A

Heat increases absorption

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7
Q

rate limits on simple diffusion

A
  • capillary amount
  • solubility
  • molecular size and composition
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8
Q

Compartment 1 of multi compartment model

A

general circulation

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9
Q

compartment 2 of multi-compartment model

A

Organs

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10
Q

Compartment 3 of multi-compartment model

A

Fatty tissue

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11
Q

Hydrophilic drugs tend to stay in which compartment?

A

compartment 1

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12
Q

what is not given to kids without adult teeth?

A

tetracyclines

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13
Q

what type of drug can focus on fetal circulation?

A

Med with Basic pH

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14
Q

drugs that are administered in their non-active form

A

prodrugs

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15
Q

most commonly used target enzyme

A

CYP3A4

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16
Q

Often provides a site for conjugation or may inactivate P450 metabolites for excretion

A

Hydrolysis

17
Q

Its easier to eliminate which compounds than which compounds?

A

easier: polar/hydrophilic

Than - Lipophilic

18
Q

3 processes of renal elimination

A
  • Glomerular Filtration
  • Active tubular secretion
  • Passive tubular reabsorption
19
Q

what med passes via Glomerular filtration?

A

Unbound meds

20
Q

what med passes via Active tubular secretion?

A

P-Glycoproteins, and other transport proteins

21
Q

What med passes via passive tubular reabsorption

A

weak acids/bases via concentration gradients

22
Q

order of kinetics where half life is constant?

A

First order of kinetics

23
Q

order of kinetics where half life decreases with decreasing concentration

A

Zero order kinetics

24
Q

Creatinine clearance of someone on HD that day or CRRT

25
Q

Does a loading dose shorten time to steady state?

A

No, still 4-5 half-lives

26
Q

when the body makes more receptors

A

upregulation

27
Q

when the body removes receptors

A

downregulation

28
Q

Drug interaction where P450 enzymes are inhibited or inducted

A

Altered Metabolism

29
Q

Drug interaction where drugs that bind to plasma proteins may compete with other drugs for the same site

A

plasma protein competition

30
Q

in plasma protein competition, what can the kicked out competing drug cause?

31
Q

Second messengers/Biochemical messengers:

A
  • cAMP
  • cGMP
  • Ca++
  • Inositol phosphates

My Pharm 1 (10 decks)

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