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My Pharm 1 > Midterm > Flashcards

Midterm Flashcards

1
Q

fastest conducting fiber of all nerve fibers?

A

A-Alpha

largest in diameter and most heavily myelinated

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2
Q

slowest of the A fibers?

A

Delta

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3
Q

fiber for motor function and proprioception?

A

A-Alpha

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4
Q

Fiber for motor function, touch, and pressure sensation?

A

A-Beta

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5
Q

Fiber for Muscle spindles and reflex?

A

A-Gamma

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6
Q

Fibers for pain and temperature sensation?

A

A-Delta

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7
Q

only fibers that are unmyelinated?

A

C fibers

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8
Q

Fibers that conduct pain and temperature impulses?

A

C fibers

A-Delta too?

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9
Q

which fibers are least sensitive to local anesthetics?

A

A-Alpha

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10
Q

which fibers are the most sensitive to LA?

A

C fibers

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11
Q

what property helps LA bind inside the nerve?

A

A tertiary Amine

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12
Q

What property makes the LA lipophilic?

A

Unsaturated aromatic ring system

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13
Q

how are Ester and amide structurally different?

A

intermediate carbon group - The linkage between the aromatic ring system and the tertiary Amine

(this is what makes the 2 different for metabolism and allergic reactions)

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14
Q

an addition of what structurally results in greater protein binding?

A

large chemical radicals

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15
Q

lipid potency correlates with what?

A

protein binding

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16
Q

LAST acronym

A

Local anesthetic systemic toxicity

17
Q

first signs of toxicity

A

tachycardia, hypertension, psychically “off”

CNS more susceptible than CVS

18
Q

most common drug for CVS toxicity?

A

Bupivicaine

19
Q

what to do if toxicity occurs?

A

intralipid infusion, at least 20-30% lipids

20
Q

largest drug incidence of TNS symptoms?

A

Lidocaine via nerve block

21
Q

What is the Eutectic (EMLA) mix of LA consist of ?

A

Lido and Prilocaine

22
Q

The termination of action of all induction drugs is what?

A

Redistribution

23
Q

which induction drugs form active metabolites?

A

midazolam
ketamine
phospropofol

24
Q

what opiates form active metabolites?

A

Morphine and Meperidine

25
Q

which opioid can prolong QT

A

Methadone

26
Q

which “fentanyl” has N/V S/E

A

remifentanyl

27
Q

opiate tolerance dose?

A

60 mg/wk

My Pharm 1 (10 decks)

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