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Antibiotics > Quinolones > Flashcards

Quinolones Flashcards

1
Q

Give some examples

A

Ciprofloxacin

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2
Q

What are the indications for use

A
  • UTI
  • Sev GI infection (shigella, campylobacter)
  • LRTI
  • Pseudomonas aeruginosa
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3
Q

Why is it sometimes reserved for 2nd/3rd line

A

Potential resistance

Ass C. Diff

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4
Q

What are the side effects

A
  • GI (nausea & diarrhoea)
  • delayed hypersensitivity
  • neuro effects (hallucinations, lowered seizure threshold)
  • inflammation & rupture of tendons
  • inc risk of arrhythmia (inc QT interval)
  • promote C.Diff colitis
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5
Q

What are the contra-indications

A
  • Caution in those with a risk of seizures
  • Caution in growing (risk of arthropathy)
  • RFs for QT prolongation (cardiac disease, electrolyte disturbance)
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6
Q

What are the interactions

A
  • Drugs with divalent cations (Ca, ANTACIDS)
  • THEOPHYLLINE
  • NSAIDs (inc risk of SE)
  • PREDNISOLONE (inc risk of tendon rupture)
  • Drugs that prolong QT interval (SSRIs, MACROLIDES, AMIODARONE, QUININE, ANTIPSYCHOTICS)
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7
Q

What is the mechanism of action

A

inhibit DNA synthesis

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Antibiotics (9 decks)

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