Quinolones Flashcards
What are the indications for Quinolones?
UTIs, respiratory tract infections, skin/soft-tissue infections, and sometimes intra-abdominal infections.
What class of antibiotics do Quinolones belong to?
Fluoroquinolones
What is the mechanism of action for Quinolones?
Inhibit DNA gyrase and topoisomerase IV (bactericidal).
What routes of administration are available for Quinolones?
Oral (excellent bioavailability) and IV.
What are the contraindications for Quinolones?
Caution in children, pregnant women, and patients with history of tendon rupture or myasthenia gravis.
Which substances, when co-administered with Quinolones, markedly reduce absorption?
Antacids, calcium, magnesium, iron, and zinc supplements.
What is a significant risk associated with co-administration of Quinolones and antiarrhythmic drugs?
QT prolongation risk.
What are some adverse effects of Quinolones?
- Tendonitis/tendon rupture
- QT interval prolongation
- CNS effects (dizziness, seizures)
- Peripheral neuropathy
With which class of drugs should Quinolones be avoided?
Class I/III antiarrhythmics.
What lab value monitoring may be warranted for high-risk patients on Quinolones?
ECG monitoring.
What nursing consideration should be taken when administering Quinolones?
Monitor for musculoskeletal pain.
What patient teaching is important regarding the timing of Quinolones with antacids or dairy?
Instruct on proper timing with antacids/dairy; report tendon pain immediately.
What foods or beverages should be avoided close to dosing of Quinolones?
Dairy or mineral supplements.
What lab monitoring is recommended while on Quinolones?
ECG (for QT) and routine labs as clinically indicated.
