Quinolones

Question 1

three drug categories that target bacterial DNA replication, transcription, and translation

Answer 1

quinolones
rifamycin derivatives
drugs that target bacterial ribosomes

Question 2

how to quinolones kill bacteria

Answer 2

broad spectrum

inhibit one or both of the 2 types of type II topoisomerases which include DNA gyrase (II (gram-) and top IV (gram +)

Question 3

3 categories of infection that fluoroquinolones treat

Answer 3

urogenital
respiratory
GI

Question 4

microbes that fluoroquinolones target

Answer 4

gram -

Question 5

three most common sources of resistance to quinolones

Answer 5

• chromosomal mutations in genes that encodes type II top
• alteration in expression of membrane porins and efflux pumps that determine the concentration of drug inside the bacteria

Question 6

how to quinolones demonstrate selective toxicity

Answer 6

differences in structures between the bacterial and eukaryotic forms of these enzymes