Chapter 33 Macrolides Flashcards
1
Q
What makes macrolides effective for pulmonary infections?
A
excellent lung tissue penetration
intracellular activity against Legionella
2
Q
What is the specific ribosomal subunit that macrolides act on and what effect does it have?`
A
23S rRNA of 50S subunit
blocks translocation of protein sythesis
3
Q
Major cause of macrolide resistance
A
methylase production –> modifies 23S RNA causing decreased drug binding
4
Q
why stop using erthromycin?
A
GI intolence –> drug can stimulate gut motility –> nausea, vomiting, diarrhea, and sometimes anorexia
