Chapter 37 Adamantanes

Question 1

MOA of adamantine

Answer 1

inhibitor of viral uncoating active exclusively against influenza A
block M2 ion channel fxn so inhibits acidification of the interior of the virion, dissociation of matrix protein, and uncoating

Question 2

what has taken over adamantine

Answer 2

rimantadine has similar MOA but less side effects; used as a prophylactic agent in influenza settings