Chapter 37 Neuraminidase Inhibitors

Question 1

MOA neuraminidase inhibitors

Answer 1

neuraminidase cleaves sialic acid from membrane glycoproteins and permits release of the virus; so w/o it the virus can’t spread to other cells and is tethered to the cell surface

Question 2

how is zanamavir administered

Answer 2

inhaler b/c it has poor oral bioavailability

Question 3

what is oseltamavir used for prophylactically

Answer 3

H5N1 avian influenza “bird flu”