QUINOLONAS Flashcards

1
Q

Cuales son las quinolonas de 1a generacion?

A

1-ACIDO NALIDIXICO (unica quinolona)

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2
Q

QUE CUBRE EL ACIDO NALIDIXICO?

A

-gram (-) sensibles (solo en cistitis), PIELONEFRITIS NO

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3
Q

Cuales son las quinolonas de 2a generacion?

A

1-CIPROFLOXACINO (unico medicamento para pseudomonas, VO, antibiotico sistemico)

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4
Q

QUE CUBRE EL CIPROFLOXACINO?

A

-gram (-), pseudomonas

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5
Q

Cuales son las quinolonas de 3a generacion?

A

1-LEVOFLOXACINO (primera linea en neumonia)

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6
Q

QUE CUBRE EL LEVOFLOXACINO?

A

-gram (+) e intracelulares, gram (-)

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7
Q

Cuales son las quinolonas de 4a generacion?

A

1-MOXIFLOXACINO

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8
Q

QUE CUBRE EL MOXIFLOXACINO?

A

-anaerobios, gram (+), intracelulares, gram (-)

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9
Q

MA de las quinolonas

A

-bloquean la actividad de la ADN girasa topoisomerosa II y de la topoisomerasa IV bacterina

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10
Q

EA de quinolonas

A
  • NO SE DA A EMBARAZADAS
  • dermatologicas
  • gastrointestinales
  • alteraciones del SNC
  • artropatia
  • anafilaxia
  • alteraciones bioquimicas (citopenias)
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11
Q

INTERACCION DE LAS QUINOLOAS

A
  • sinergico con betalactamicos
  • antiacidos disminuye su absorcion
  • antagonica (rifampicina, cloranfenicol, nitrofurantoina)
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