quick overview Flashcards
G1
Cell grows and prepares for DNA replication.
S
DNA is replicated.
G2
The cell prepares for mitosis
M
The actual division of the nucleus and cell.
what is a tumor supressor gene?
a gene that normally regulates cell growth and division, preventing uncontrolled cell growth and tumor development
what happens if tumor supressor genes are mutated?
cells can grow out of control, potentially leading to cancer.
what is a proto oncogene?
a normal gene that plays a crucial role in regulating cell growth and division
what is an oncogene?
a mutated gene that can cause cancer.
how can a proto oncogene become an oncogene?
proto-oncogene transforms into an oncogene through various genetic changes, including mutations
binary fission steps (5)
- DNA replicates
- Cell grows and elongates
- DNA segregates
- A septum begins to form in the center of the cell
- The septum fully divides the cell into two identical daughter cells.
what does the m checkpoint check for?
chromosome spindle attachment
what does g1 checkpoint check for?
the cell checks if it has adequate size, nutrients, and intact DNA
what does the g2 checkpoint check for?
- cell size
- dna replication
what happens in g1
the cell grows and increases the volume of protein and organelles
what happens in s phase
cell replicates its DNA
what happens in g2 phase
the cell prepares for the mitotic division
what happens in m phase
cell division
what is a caspase
a protein that regulates programmed cell death (apoptosis) and inflammation
what is a bleb
a balloon-like outgrowth of the plasma membrane
what is a apoptotic body
remnants of cells having undergone apoptosis
what is a phagocyte
a scavenging cell that engulfs and absorbs cell
particles and bacteria
steps of apoptosis (6)
- Internal or external signals (like DNA damage or stress) trigger apoptosis.
- The cell begins to shrink and its membrane starts to bleb
- The chromatin (DNA) inside the nucleus condenses and clumps together.
- The DNA is broken into small pieces by enzymes (like caspases).
- The cell breaks into small, membrane-bound fragments called apoptotic bodies. These bodies contain pieces of the cell, including the fragmented DNA.
- The apoptotic bodies are recognized and engulfed by nearby cells (like immune cells), which clean up the cell remnants without causing inflammation.
internal triggers of apoptosis
cell damage (radiation, damages DNA)
external triggers of apoptosis
death receptor pathway