QUANTEC Dose Tolerances

Question 1

Skin

Answer 1

Telangiectasia = 50Gy to 100cm2 (10x10 field)
Gangrene, necrosis, ulceration = 55Gy to 100cm2 (10x10 field)

Question 2

Femoral Heads and Necks

Answer 2

Osteoradionecrosis = V50<50%

Question 3

Small Bowel

Answer 3

RTOG grade 3 (Obstruction, bleeding) = Volume receiving 45Gy should be less than 195cc for a less than 10% chance

Question 4

Bladder

Answer 4

RTOG grade 3 (frequency, dysuria, telangiectasia, hematuria, reduction in capacity) = Max dose of 65Gy to whole organ creates less than 6% chance

Question 5

Rectum

Answer 5

RTOG grade 2/3 (Diarrhea, colic, frequency, bleeding, rectal mucus) (bleeding, obstruction) = V50<50%, V60<35%, V65<25% for a less than 10% chance

Question 6

Penile Bulb

Answer 6

Severe erectile dysfunction = V50<90% for a less than 35% chance

Question 7

Stomach

Answer 7

Ulceration, mucosal erosion, perforation = 45Gy to whole organ for a less than 7% chance

Question 8

Kidneys

Answer 8

Clinical dysfunction = V28<20% for a less than 5% chance

Question 9

Esophagus

Answer 9

RTOG grade 3 (esophagitis = Severe Fibrosis) = Mean dose of 34Gy creates a 5-20% chance

Question 10

Heart

Answer 10

Cardiac mortality = V25<10% for a less than 1% chance

Question 11

Brachial Plexus

Answer 11

Brachial plexopathy = V60<5%

Question 12

Lung

Answer 12

Symptomatic pneumonitis = V20<30% for a 20% chance

Question 13

Spinal Chord

Answer 13

Myelitis, necrosis leading to paralysis = max dose of 50Gy to partial organ creates less than 0.2% chance