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biochem > q8 > Flashcards

q8 Flashcards

1
Q

where does ets occur

A

mitochondrial membrane

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2
Q

what is the route for NADH

A

NADH –> comp1 –> Q –> comp3 –> cyt c –> comp4 –> O2

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3
Q

what is the route for FADH2

A

FADH2 –> comp2 –> QH2 –> comp3 –> cyt c –> comp4 –> O2

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4
Q

how many H+ are pumped during NADH? during FADH2?

A

10
6

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5
Q

what inhibit ets

A

rotenone, hydrogen cyanide, CO, and antimycin A

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6
Q

describe comps 1,3,4

A

multi-subunits that move proton across IMM

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7
Q

describe coenzyme q

A

small hydrophobic e- carrier
comp1/2–>comp3

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8
Q
A
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9
Q

describe cytochrome c

A

small water soluble protein in intermembrane
1 e-
comp 3&4

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10
Q

name: comp 1
comp 2
comp 3
comp 4

A

ubiquinone oxidoreductase
succinate dehydrogenase
cytochrome c oxidoreductase
cytochrome c oxidase

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11
Q

describe redox centers

A

bound to proteins in ETS

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12
Q

how many protons does NADH ubiquinone oxidoreductase pump

A

4

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13
Q

what is the net rxn for NADH ubiquinone oxidoreductase

A

NADH + Q + 5H+n —> QH2 + 4H+p

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14
Q

what is the net rxn for succinate dehydrogenase

A

FADH2 + Q —> FAD + QH2

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15
Q

how many protons does ubiquinone cytochrome c oxidoreductase pump

A

4

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16
Q

how many protons does ubiquinone cytochrome c oxidoreductase pump

A

4

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17
Q

what is the net rxn of ubiquinone cytochrome c oxidoreductase

A

QH2 + 2H+n + 2 cytochrome c —> Q + 4H+p + 2 cytochrome c

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18
Q
A
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19
Q

when does the q cycle occur

A

in comp3

20
Q

what are the 4 steps of the q cycle

A
  1. oxidation at QH2
  2. oxidized Q to Qn
  3. new QH2 binds to Qp
  4. second e- reduces semiquinone
21
Q

describe cytochrome c

A

comp3 —> comp4
small and associated with cytosolic side of IMM
highly conserved

22
Q

describe cytochrome c oxidase

A

homodiamer
pumps 2H+ into intermembrane space

23
Q

how many protons are brought in with NADH?
with FADH2?

A

10
6

24
Q

what are the 3 unites for ATP synthase

A

rotor
catalytic headpiece
stater

25
Q

what is the F1 component

A

the catalytic head
binds ADP and Pi
releases ATP
no rotation
y subunit will cause rotation and conformational change

26
Q

describe the stater

A

stationary
protons are able to enter and exit c-ring
attaches F0 to F1

27
Q

describe F0

A

2 proton half channels embedded in the membrane
c-ring rotates with proton flow with 10 helices

28
Q

describe half channels

A

Hp+ enters via Hp+ channels
Hp+ protonates asp59
~36 rotations of c-ring
protonated asp59 released H+ to n-side through Hn+ channel

29
Q

describe ATP/ADP translocase

A

imports 1 ADP to matrix and exports 1 ATP to inter membrane state

30
Q

describe phosphate translocase

A

channel proteins
symports Pi and H+
antiports Pi and OH-

31
Q

how many H produce 1ATP

A

4

32
Q

describe cytosolic DNA

A

created in glycolysis
e- can only cross the membrane via shuttle systems

33
Q

important #

A
34
Q

important numbers

A
35
Q

important numbers

A
36
Q

net rxns

A
37
Q

describe malate-aspartate shuttle

A

liver/heart/kidney/etc
produces 10H+ or 2.5 ATp

38
Q

describe glycerol-3-phosphate shuttle

A

muscle and skeletal tissue
NADH reduces FAD
faster and more simple
produces 6H+ or 1.5 ATP

39
Q

what happens if energy charge is high

A

processes will be inhibited

40
Q

most reactants are _________ and most products are ________

A

activators
inhibitors

41
Q

what activates many pathways

A

ADP and Pi

42
Q

what does 2,4-dnp do

A

transports H+ but does not synthesize ATP
uncoupled H+ circuit from ATP synthase

43
Q

what can inhibit complex IV

A

cyanide

44
Q

what does oligomycin block

A

ATP synthase

45
Q
A

biochem (11 decks)

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