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q8 Flashcards

1
Q

where does ets occur

A

mitochondrial membrane

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2
Q

what is the route for NADH

A

NADH –> comp1 –> Q –> comp3 –> cyt c –> comp4 –> O2

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3
Q

what is the route for FADH2

A

FADH2 –> comp2 –> QH2 –> comp3 –> cyt c –> comp4 –> O2

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4
Q

how many H+ are pumped during NADH? during FADH2?

A

10
6

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5
Q

what inhibit ets

A

rotenone, hydrogen cyanide, CO, and antimycin A

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6
Q

describe comps 1,3,4

A

multi-subunits that move proton across IMM

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7
Q

describe coenzyme q

A

small hydrophobic e- carrier
comp1/2–>comp3

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8
Q
A
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9
Q

describe cytochrome c

A

small water soluble protein in intermembrane
1 e-
comp 3&4

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10
Q

name: comp 1
comp 2
comp 3
comp 4

A

ubiquinone oxidoreductase
succinate dehydrogenase
cytochrome c oxidoreductase
cytochrome c oxidase

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11
Q

describe redox centers

A

bound to proteins in ETS

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12
Q

how many protons does NADH ubiquinone oxidoreductase pump

A

4

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13
Q

what is the net rxn for NADH ubiquinone oxidoreductase

A

NADH + Q + 5H+n —> QH2 + 4H+p

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14
Q

what is the net rxn for succinate dehydrogenase

A

FADH2 + Q —> FAD + QH2

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15
Q

how many protons does ubiquinone cytochrome c oxidoreductase pump

A

4

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16
Q

how many protons does ubiquinone cytochrome c oxidoreductase pump

A

4

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17
Q

what is the net rxn of ubiquinone cytochrome c oxidoreductase

A

QH2 + 2H+n + 2 cytochrome c —> Q + 4H+p + 2 cytochrome c

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18
Q
A
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19
Q

when does the q cycle occur

20
Q

what are the 4 steps of the q cycle

A
  1. oxidation at QH2
  2. oxidized Q to Qn
  3. new QH2 binds to Qp
  4. second e- reduces semiquinone
21
Q

describe cytochrome c

A

comp3 —> comp4
small and associated with cytosolic side of IMM
highly conserved

22
Q

describe cytochrome c oxidase

A

homodiamer
pumps 2H+ into intermembrane space

23
Q

how many protons are brought in with NADH?
with FADH2?

24
Q

what are the 3 unites for ATP synthase

A

rotor
catalytic headpiece
stater

25
what is the F1 component
the catalytic head binds ADP and Pi releases ATP no rotation y subunit will cause rotation and conformational change
26
describe the stater
stationary protons are able to enter and exit c-ring attaches F0 to F1
27
describe F0
2 proton half channels embedded in the membrane c-ring rotates with proton flow with 10 helices
28
describe half channels
Hp+ enters via Hp+ channels Hp+ protonates asp59 ~36 rotations of c-ring protonated asp59 released H+ to n-side through Hn+ channel
29
describe ATP/ADP translocase
imports 1 ADP to matrix and exports 1 ATP to inter membrane state
30
describe phosphate translocase
channel proteins symports Pi and H+ antiports Pi and OH-
31
how many H produce 1ATP
4
32
describe cytosolic DNA
created in glycolysis e- can only cross the membrane via shuttle systems
33
important #
34
important numbers
35
important numbers
36
net rxns
37
describe malate-aspartate shuttle
liver/heart/kidney/etc produces 10H+ or 2.5 ATp
38
describe glycerol-3-phosphate shuttle
muscle and skeletal tissue NADH reduces FAD faster and more simple produces 6H+ or 1.5 ATP
39
what happens if energy charge is high
processes will be inhibited
40
most reactants are _________ and most products are ________
activators inhibitors
41
what activates many pathways
ADP and Pi
42
what does 2,4-dnp do
transports H+ but does not synthesize ATP uncoupled H+ circuit from ATP synthase
43
what can inhibit complex IV
cyanide
44
what does oligomycin block
ATP synthase
45

biochem (11 decks)

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