Pyruvate Flashcards
what is pyruvate
a glycolytic end product
- potential weight loss or ergogenic aid
what was the initial kind of discovery
a fishing expedition
what was the first model used
reduction of alcohol induced Fatty liver
do DHA and pyruvate work together dependently or independently
dependently
DHA
dihydroxyacetone
- similar in structure to pyruvate
DHA + pyruvate =
decrease in liver lipids produced by ethanol
does DHA or pyruvate alone decrease liver lipids produced by ethanol
NO
in rodents there are some evidence that pyruvate and DHA
- reduce food intake
- increased energy expenditure
- increased fat oxidation
4.increased thyroxine (T4)
T or F Metabolic rate goes up in pyruvate + DHA energy expenditure in rats
T
what thyroid hormone is most active and shows an affect
T3
what makes the zurker rat the zurker rat
absence of the leptin receptor (different from ob/ob mouse)
food intake is _____, but does not entirely predict the ______ weight gain with pyruvate and DHA
decreased, reduced
pair fed –> Liver TGs = ______
increased
Pyruvate alone VO2
increases and caloric expenditure
in pyruvate alone
all three groups gained less weight
what is futile cycling
cycle or loop that burns ATP
muscle pyruvate ____ in excess of what PDH can convert to acetyl CoA or entry into Span II of Krebs
increase
pyruvate kinase
creates ATP
PEPCK and pyruvate carboxylase
consumes energy
what is the ratio from produced eneergy to consumed in the futile cycle
2:1
early findings of high pyruvate concentration in diet of human
improved weight loss, prevented weight regain, lower plasma cholesterol
who holds the patent of the pyruvate application
richard stanko
application of pyruvate
weight loss etc.
characteristics of stanko’s studies
- morbidly obese patients
- confined to metabolic wards
- very restricted diets
high dosages (25g pyr or 75g of DHA)
