exercise and type 1 diabetes Flashcards
what is the main problem of T1D
lack of insulin
how can skeletal muscle be effected by T1D
may be some muscle damage and possible loss of insulin sensitivity
in T1D there are _____ maximal capacity for mitochondrial respiration
lower
in T1D there are ______ sensitivity to ____ concentrations of ADP
lower and low
in T1D there is ________ Ca2+ handling
poorer
ATP and PCr in individuals with T1D is generated…
normally
Impaired PCr recovery may occur if there is _________ impairment
mitochondrial
______________ may be low if poor glycemic control
hepatic [glycogen]
HGP is ____ if insulin is ____, or elevated if insulin is ____
impaired, high, low
_____ insulin levels will _____ lipolysis/fat oxidation
high, suppress
_____ insulin will promote promote protein catabolism
low
insulin normally ______ rapidly with exercise (due to ______)
decreases, catecholamines
why does insulin normally decrease
it facilitates fatty acid and glucose mobilization to maintain Bld glucose
during recovery from exercise, insulin will normally
increase due to removal of sympathoadrenal drive
why does insulin increase during recovery
prevents excessive hyperglycemia following intense exercise (lots of GNG precursors still present)
