PYRETHROIDS

Question 1

Substances

Answer 1

Tetramethrin (NeoStomosan) → 1st gen.
Permethrin (ExSpot, Advantix, Vectra) → 2nd gen.
Deltamethrin (Scalibor) → 2nd gen.
Flumethrin (Kiltix, Foresto) → 2nd gen.

1st generation: toxicity, residual activity, lower stability

Question 2

Mechanism of action

Answer 2

Na+ - channels ↑
↓
constant depolarization „knock-down effect”

CONTACT POISON + REPELLENT

Question 3

Application

Answer 3

Ticks: still OK 
Fleas: resistance is common 
Poor efficacy against mange mites 
Fly control 
Moderate efficacy against Varroa mites (resistance!)

Question 4

Toxicity

Answer 4

Safe in warm-blooded animals (↔ cat spot on)
Tremors, seizures, excitation
Fish are especially sensitive
Antidote Ø
Intralipid 20% sequestration
Favourable prognosis in most cases (within 24 hours)
+ LOCAL IRRITATION, ALLERGIC REACTIONS